Clin2
NCT07715747Possibly a fitNot yet recruiting

TJ037130 for advanced solid tumors

Solid TumorMetastatic Ovary CancerMetastatic Gastric CancerMetastatic Endometrial Carcinoma

Part of Cancer, Digestive system, Hormones & metabolism, Women’s health & pregnancy clinical trials.

This trial tests an investigational drug called TJ037130 in people with advanced solid tumors that have not responded to standard treatments or for whom no standard treatment is available. The drug targets a protein called Claudin 6 on tumor cells and may help your immune system fight the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
128 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You must be physically able to perform daily activities (ECOG 0 or 1).
  • Your tumor must have tested positive for Claudin 6 protein (by a lab test).
  • You must have advanced cancer that has spread or come back, and standard treatments are no longer working or are not suitable.
  • You must have at least one tumor that can be measured or evaluated by scans.
  • You must not have had certain prior cancer treatments (like PD-1/PD-L1 inhibitors) within the last 28 days, and no prior treatments targeting Claudin 6 or 4-1BB.
  • You must be willing to use effective contraception if you or your partner can have children.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06809114Recruiting· Phase 1
Study of AT03-65 for advanced CLDN6-positive solid tumors

This early-phase trial tests an investigational drug (AT03-65) for people with advanced solid tumors that have a certain protein called CLDN6. The goal is to see if the drug is safe and if it might help shrink tumors.

Denver, Colorado
NCT07595237Recruiting· Early Phase 1
Radioactive treatment for advanced solid tumors with Claudin18.2

This early-stage trial tests a new radioactive drug (177Lu-DOTA-SNA040) designed to target a protein called Claudin18.2 found on certain cancer cells. The drug delivers radiation directly to tumors in patients with advanced gastric, pancreatic, or bile duct cancers that have stopped responding to standard treatments.

Shanghai, Shanghai Municipality
NCT05205850Recruiting· Phase 1/Phase 2
RC118 for solid cancers with Claudin 18.2 on tumor cells

This Phase 1/2 study tests RC118, a cancer medicine, in people with advanced or spread solid tumors that cannot be removed by surgery. It focuses on tumors that show a specific marker called Claudin 18.2, which may help the treatment work better for some patients.

Shanghai, Shanghai Municipality
NCT06276491Recruiting· Phase 1
Safety study of an investigational drug for advanced cancer with the CLDN6 marker

This trial tests an investigational drug for people with advanced solid tumors, especially ovarian, fallopian tube, peritoneal, endometrial, or germ cell cancers that have a specific marker called CLDN6. The goal is to see if the drug is safe and tolerable.

Duarte, California
NCT06782425Recruiting· Phase 1
Cell therapy for advanced stomach cancer with Claudin18.2 protein

This trial tests a new type of cell therapy (CAR-T) that targets a protein called Claudin18.2 found on some stomach, esophagus, and gastroesophageal junction cancers. The goal is to see if this treatment can shrink tumors or stop them from growing when other treatments have stopped working.

Anyang, Henan
NCT07460375Recruiting· Phase 1/Phase 2
Study of LCB02A for advanced solid tumors with Claudin 18.2

This trial tests a new drug called LCB02A, which targets a protein called Claudin 18.2 found on some cancer cells. It is for people with advanced solid tumors that have not responded to standard treatments.

Boston, Massachusetts

Hear when a new Solid Tumor trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.