Clin2
NCT07726875Possibly a fitEnrolling by invitation

Orexin and confusion after surgery in older adults

Emergence Delirium, Anesthesia

Part of Brain & nervous system, Mental health clinical trials.

This study looks at a brain chemical called orexin (which helps control wakefulness) in older adults after surgery. The goal is to see if orexin levels are linked to confusion or agitation that can happen when waking up from anesthesia. If you take part, your blood will be tested before and after surgery.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
150 people
Ages
60 years and older
Study type
Observational

Who can take part

  • You are 60 years old or older
  • You are scheduled for a non-heart surgery that will last at least 2 hours under general anesthesia
  • You do not have a diagnosed mental illness or take antidepressants/antipsychotics
  • You do not have a sleep-wake disorder or take related medications
  • You do not have severe liver, kidney, or anemia problems

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05555693Recruiting
Brain chemistry study after surgery in older adults

This study looks at how brain “metabolomics” (small chemical signals in the brain/body) relate to thinking or mood problems that can happen after surgery in people age 65 and older. It may help doctors understand who is more likely to have these side effects after an operation.

Shanghai, Shanghai Municipality
NCT06958393Not yet recruiting· Phase 4
Opioid-free anaesthesia for reducing confusion after stomach surgery in older adults

This study tests whether avoiding opioid painkillers during anaesthesia can reduce confusion after surgery in older adults. It is specifically for people 65 and older having stomach or intestine surgery.

Jinan, Shandong
NCT06423547Recruiting
Predicting confusion after surgery in older adults

This study looks at older patients (65 and older) who have had surgery and anesthesia. It aims to find who is at risk for confusion (delirium) and memory problems afterward. The goal is to help doctors prevent these issues.

Beijing
NCT07695285Not yet recruiting· Phase 2
Sleep medication to improve confusion after surgery in older adults

This study tests whether a sleep medication called lemborexant can help older adults recover their thinking and memory more quickly after surgery. It may reduce confusion or delirium that sometimes happens after an operation.

NCT07108764Recruiting
Medicine to prevent confusion after abdominal surgery in seniors

This trial tests giving either lidocaine or dexmedetomidine during abdominal surgery to see if it helps keep the brain healthy and lowers the chance of waking up confused or agitated. It is for older adults having planned abdominal surgery who are otherwise in fairly good health.

Tanta, El-Gharbia
NCT07463586Recruiting
Brain oxygen and confusion after surgery in older adults

This study looks at how giving extra oxygen during surgery affects brain function and confusion (delirium) in older adults. It involves placing a small sensor on your forehead to measure brain oxygen levels.

Seongnam-si, Gyeonggi-do

Hear when a new Emergence Delirium, Anesthesia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.