Drug combination before surgery for advanced mouth cancer
Part of Cancer, Mouth & dental clinical trials.
This trial tests a combination of two drugs (pembrolizumab and cetuximab) given before surgery for advanced mouth cancer linked to betel nut chewing. The goal is to see if this combination can shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have mouth cancer (oral cavity squamous cell carcinoma) that has been confirmed by biopsy.
- You have a history of chewing betel nut (paan or supari).
- Your cancer is locally advanced (stage III or IV) but has not spread to distant organs.
- You have not had any prior treatment (surgery, radiation, or chemotherapy) for this cancer.
- You are generally able to care for yourself (ECOG score 0–3).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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