Flonoltinib for myelofibrosis
Part of Blood & lymphatic clinical trials.
This trial tests an oral medicine called flonoltinib maleate for people with myelofibrosis. It may help reduce an enlarged spleen and improve symptoms like fatigue and night sweats.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have a diagnosis of myelofibrosis (including primary or secondary types).
- Your spleen is enlarged (can be felt at least 5 cm below the ribs or confirmed by scan).
- You have symptoms like fatigue, night sweats, or belly pain from the disease.
- Your blood counts meet certain limits, and you are not dependent on growth factors or blood transfusions.
- You are not planning a stem cell transplant within the next 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two oral medications for people with myelofibrosis, a type of bone marrow cancer. It may be an option if you have not been helped by standard JAK inhibitor therapy or if you have never tried one.
This trial tests an experimental drug called PMD-026 for people with myelofibrosis that has not responded well to a JAK inhibitor (like ruxolitinib). The goal is to see if PMD-026 can help reduce symptoms and spleen size.
This trial tests an oral drug called tasquinimod for people with myelofibrosis that no longer responds to or cannot take a JAK inhibitor. The goal is to see if tasquinimod can help shrink an enlarged spleen and improve symptoms.
This trial tests two new medicines, selinexor and pacritinib, for people with myelofibrosis who have low blood counts and have not yet tried JAK inhibitor therapy. The goal is to see if this combination helps reduce spleen size and improve blood counts.
This trial tests whether adding TL-895 to ruxolitinib can improve outcomes in adults with myelofibrosis. It focuses on people who are not getting enough benefit from ruxolitinib or who need treatment as part of the study.
This trial tests a new drug called revumenib, which is being studied for people with myelofibrosis. Revumenib may help slow the disease and improve symptoms. The study has two parts: one for people who have already tried a JAK inhibitor, and one for those currently on a JAK inhibitor but still have active disease.
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