Vonoprazan test for acid reflux that doesn't respond to standard medicine
Part of Digestive system clinical trials.
This trial tests a medicine called vonoprazan for people whose acid reflux symptoms (like heartburn or coughing) don't get better with usual treatment. It aims to see if vonoprazan can help control those symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 20 and 75 years old
- You have ongoing acid reflux symptoms such as heartburn, chest pain, or a chronic cough despite taking standard reflux medicine for at least 8 weeks
- You had an upper endoscopy (a camera test of your stomach and esophagus) in the last year
- You are scheduled for special tests on your esophagus (manometry and pH-impedance monitoring)
- You do not have certain serious conditions like major swallowing problems, past stomach surgery, cancer, or severe kidney disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a newer medication called vonoprazan against the standard treatment pantoprazole for patients with gastroesophageal reflux disease (GERD). The goal is to see which one works better for controlling symptoms like heartburn and acid reflux over 8 weeks.
This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.
This study tests a new medicine called vonoprazan to see if it can reduce episodes of heartburn in people who have GERD but no damage to their esophagus. It compares the medicine to a placebo (a pill with no active ingredient) over 24 weeks.
This trial compares two medicines—vonoprazan and esomeprazole—to see which is better at healing acid damage to the esophagus (erosive esophagitis). If you have had heartburn and an endoscopy confirmed inflammation, you may be eligible for this study.
This trial tests whether vonoprazan can reduce ulcers caused by a procedure that ties off enlarged veins in the esophagus (variceal band ligation). It is meant for people with liver cirrhosis who are scheduled to receive this treatment.
This trial compares two different antibiotic combinations to treat H. pylori, a common stomach bacteria that causes indigestion and ulcers. One uses a newer acid-blocking medicine (vonoprazan) and the other uses a standard one (esomeprazole), both paired with antibiotics.
Hear when a new Refractory GERD trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.