Weight loss medicine before joint replacement surgery
Part of Bones, joints & muscles, Hormones & metabolism clinical trials.
This study looks at whether taking a GLP-1 medication (a type of medicine that helps with weight and blood sugar) before hip or knee replacement surgery can improve recovery. It may help reduce complications and improve outcomes for people who are overweight or have obesity-related health conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 90 years old
- You have arthritis in your hip or knee and are scheduled for a joint replacement surgery
- You have a BMI of 35 or above with an obesity-related health condition (like type 2 diabetes, high blood pressure, or sleep apnea) OR a BMI of 40 or above
- You are able to understand and agree to the study plan
- You are willing to stop smoking before surgery (if you smoke)
- You are not currently taking a GLP-1 medication, such as Ozempic or Wegovy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a joint health program for people with knee osteoarthritis and a BMI of 27 or higher. The goal is to see if it can improve knee pain and help with weight management.
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
This study looks at whether a type of diabetes medicine called GLP-1 analogues (like Ozempic) might affect the risk of developing osteoarthritis (a common type of arthritis that wears down joints). If you have type 2 diabetes and have been taking either a GLP-1 medicine or another type called SGLT2 inhibitors for at least a year, this trial may help you understand your joint health.
This trial tests whether adding a GLP-1 receptor agonist (a medication that helps control blood sugar and appetite) after weight loss surgery improves outcomes for people with severe obesity and related health problems like type 2 diabetes.
Hear when a new Arthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.