Fecal transplant for immune recovery after stem cell transplant
Treatments studied
This study tests whether a fecal microbiota transplant (FMT) — putting healthy donor bacteria into your gut — can help your immune system recover better after a stem cell transplant. It is for people whose immune markers are still low 6 months after transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have received or will receive your first stem cell transplant from a donor (allogeneic).
- You are willing to attend scheduled visits and provide blood or stool samples.
- For the second phase (the FMT part), your immunoglobulin A (IgA) level must be very low, and your other immune markers (IgG, IgM) have not returned to normal.
- You must not have active severe graft-versus-host disease (GVHD) — a condition where donor cells attack your body.
- You must be off antibiotics for at least 2 weeks before the FMT part, and you cannot be on high-dose steroids (more than 1 mg per kilogram per day of prednisone or equivalent).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a fecal transplant (FMT) can help treat gut graft-versus-host disease (gut GVHD), a condition where donated immune cells attack the intestines. If you have gut GVHD and meet age requirements, you may be eligible to receive this treatment in the trial.
This trial tests whether transferring healthy gut bacteria from a donor to patients can help heal severe intestinal damage that occurs after bone marrow or stem cell transplants. The goal is to reduce pain, inflammation, and other complications from this serious side effect.
This study looks at how well fecal microbiota transplantation (FMT) works over time and checks its safety. If you have received at least one FMT for a qualifying condition, you may be able to participate.
This trial tests whether fecal microbiota transplantation (Washed Microbiota Transplantation, or WMT) can help people who have gut problems like diarrhea, constipation, or infection after receiving a solid organ transplant. It aims to restore healthy gut bacteria.
This study tests whether transplanting healthy donor stool into the gut can help children and young adults with ongoing digestive issues after a stem cell transplant. It may improve symptoms like diarrhea or the need for feeding tubes.
This Phase 2 study tests whether a fecal microbiota transplant (a processed transplant of gut bacteria) after an allogeneic bone marrow transplant is safe and helpful. Participants may benefit by improving recovery in the gut microbiome during the post-transplant period.
Hear when a new Hematopoietic Stem Cell Transplantation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.