Tirzepatide for frequent bowel movements after J-pouch surgery
Treatments studied
Part of Digestive system clinical trials.
This study tests whether the medicine tirzepatide (Mounjaro) can reduce frequent bowel movements in people with a J-pouch after ulcerative colitis surgery. It aims to improve quality of life by decreasing the number of daily bowel movements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 80 years old.
- You must have a J-pouch (a surgically created internal pouch) and have more than 8 bowel movements a day on most days.
- You must have tried anti-diarrheal medicines (like loperamide or diphenoxylate/atropine) without success, or you must be unable to take them.
- You must not have taken tirzepatide or any other GLP-1 medicine before.
- You must not have type 1 or type 2 diabetes.
- You must not have significant inflammation in your pouch.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study tests a medicine called tirzepatide to see if it can help people with active Crohn’s disease who have not responded to multiple prior treatments. It focuses on how the drug might work beyond just reducing inflammation.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This study tests whether a natural supplement called Aquamin (a red algae-derived mineral source) can help prevent inflammation in people who have had surgery for ulcerative colitis and now have a J-pouch. It aims to see if this supplement reduces pouch inflammation and related symptoms.
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
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