Tirzepatide for frequent bowel movements after pouch surgery
Treatments studied
Part of Digestive system clinical trials.
This study tests a medication called tirzepatide to see if it can reduce the number of daily bowel movements in people who have had pouch surgery for ulcerative colitis and still have very frequent bowel movements (more than 8 per day) despite trying standard anti-diarrheal treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 and under 80 years old
- You have had pouch surgery (ileal pouch-anal anastomosis) for ulcerative colitis, and the final surgery was at least 6 months ago
- You have more than 8 bowel movements a day on most days despite trying loperamide (Imodium) or other anti-diarrheal medicines
- You have not taken tirzepatide or similar GLP-1 medicines before
- You agree to use the internet to enter data for the study
- You are not pregnant or breastfeeding and agree to use effective contraception if you could become pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This Phase 2 study tests whether tirzepatide can improve how your body handles fat (especially in people with overweight or obesity) and reduce fat-related “lipotoxicity.” It may help with body fat function and related health markers, but you must meet specific health and medication rules.
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