Etrasimod to prevent pouchitis after ulcerative colitis surgery
Treatments studied
Part of Digestive system clinical trials.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You had your colon removed and a pouch created because of severe ulcerative colitis or precancerous changes.
- You are at high risk for pouchitis or have had only one episode that resolved after antibiotics.
- You currently have no or very few symptoms related to your pouch.
- You have not used biologics or certain other advanced medications since your pouch surgery.
- You do not have Crohn's disease, chronic pouchitis, or other serious medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
This study tests whether a common anti-inflammatory medicine, called 5-ASA, can help prevent pouchitis (an inflammation of the surgically created pouch) in people with ulcerative colitis who have had restorative surgery.
This study tests an oral treatment made from bacteria-killing viruses (phages) for pouchitis, a common complication after surgery for ulcerative colitis. The goal is to see if it safely reduces inflammation and symptoms in the pouch.
This trial tests if the medicine etrasimod can help children with moderate to severe ulcerative colitis. You may still be able to join even if you are already taking other treatments for your condition.
Hear when a new Pouchitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.