Rifaximin to prevent pouchitis from coming back
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had ulcerative colitis and have had pouch surgery (IPAA) with the ileostomy closed.
- Your first pouchitis episode happened within 12 months after that surgery.
- You do not have Crohn's disease or a current C. diff infection.
- You are not on long-term antibiotics (like for acne) and have not had a fecal transplant recently.
- You do not have severe liver or kidney disease, and you're not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
This trial tests whether a medicine applied to the pouch after surgery can prevent pouchitis (inflammation of the pouch) in people with ulcerative colitis who have had their colon removed and a pouch created. It may help avoid the discomfort and complications of pouchitis.
This study looks at whether adding tryptophan, a natural substance found in food, can help improve treatment for pouchitis, which is inflammation in a surgically created internal pouch. It aims to see if it makes antibiotics and probiotics work better.
This trial tests whether an oral antibiotic called rifaximin can improve symptoms during a microscopic colitis flare. It aims to see if it is safe and effective for people whose colitis was confirmed by colon biopsy.
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