Two medicines for recent-onset POTS with allergy symptoms
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This early-stage trial tests two medicines (guanfacine and cromolyn sodium) to see if they help with POTS symptoms like dizziness and rapid heartbeat. It's looking for people whose POTS started recently after a trigger and who may have signs of allergic-type reactions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of POTS, meaning your heart rate jumps by 30 beats per minute or more within 10 minutes of standing, and you don't have a big drop in blood pressure when standing.
- You have symptoms like dizziness, heart palpitations, or stomach issues that have lasted at least 3 months.
- Your symptoms started within 3 months after something like an infection, a vaccine, an injury, surgery, pregnancy, or reaching puberty.
- You have symptoms like flushing, itching, hives, or swelling — or you've had a positive response to allergy-type medications.
- You don't have another medical condition (like anemia, active infection, dehydration, thyroid issues, or certain tumors) that could explain your symptoms.
- You're not pregnant or breastfeeding, and you're not taking any medications that can't be safely paused for the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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