Adding probenecid to amoxicillin for bone and joint infections
This trial tests whether adding a drug called probenecid can help amoxicillin work better in your body for treating bone and joint infections. If you are already taking amoxicillin for such an infection, adding probenecid might increase the amount of amoxicillin in your blood, potentially making the treatment more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years of age or older.
- You have a bone or joint infection (like arthritis, osteomyelitis, or infection near a joint replacement) that is being treated with amoxicillin by mouth.
- You have a lab test confirming that the bacteria causing your infection can be killed by amoxicillin.
- You will stay in the hospital for at least 4 days after joining the study.
- You are not pregnant or breastfeeding, and you agree to use effective birth control if you are a woman who could become pregnant.
- You do not have severe kidney or liver problems, and you weigh between 40 and 110 kg (about 88 to 242 pounds).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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