Using probenecid to boost amoxicillin for bone and joint infections
Part of Bones, joints & muscles, Infections clinical trials.
This trial tests whether adding a medicine called probenecid to your regular amoxicillin treatment keeps the antibiotic working longer in your body for bone or joint infections. If eligible, you'll stay in the hospital for a few days while the study team closely monitors your treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a bone or joint infection (like arthritis, osteomyelitis, or spondylodiscitis) that is being treated with the antibiotic amoxicillin taken by mouth.
- You must be able to stay in the hospital for at least 4 days after joining the study.
- You cannot be pregnant or breastfeeding, and if you are a woman who could become pregnant, you must use effective birth control during the study.
- You must not have certain medical conditions, such as severe kidney problems, recent gout attack, or a severe allergy to penicillin-type antibiotics.
- You must not be taking certain medications that interact with the study drug (like methotrexate or phenobarbital).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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