Immunotherapy, targeted therapy, and radiation for liver cancer with portal vein clot
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial combines two immunotherapy drugs with a targeted therapy, radiation, and a liver-directed chemotherapy infusion for liver cancer that has spread to the portal vein (the main blood vessel to the liver). The goal is to see if this combination can shrink tumors and help people live longer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with liver cancer (hepatocellular carcinoma).
- Your cancer has spread into the portal vein (the main vessel bringing blood to the liver), a condition called portal vein tumor thrombus.
- You have not had any previous treatment for this cancer, such as surgery, radiation, chemotherapy, or immunotherapy.
- Your liver is still working reasonably well (Child-Pugh score of 7 or less).
- You are not eligible for curative surgery or transplant, but you can receive radiation therapy.
- You are able to perform daily activities with minimal help (ECOG score 0 or 1).
- You have no active hepatitis B or C, and no history of radiation to the belly or pelvis.
- For women who can become pregnant, you agree to use effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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