Genetic study of auditory neuropathy spectrum disorder (ANSD) caused by the OTOF gene
Part of Brain & nervous system, Ear, nose & throat clinical trials.
This study looks at the genes that cause a specific type of hearing loss called auditory neuropathy spectrum disorder (ANSD), where sound reaches the ear but the brain has trouble processing it. By studying DNA from people with this condition, researchers hope to better understand the genetic causes and improve diagnosis and treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of auditory neuropathy spectrum disorder (a hearing issue where sound reaches the ear but the brain has trouble understanding it) that is not linked to a larger medical syndrome.
- Your hearing test shows that you can hear sounds but have trouble understanding speech, and the brain's response to sound is abnormal.
- You may have some inner ear responses (otoacoustic emissions) that are present, which is often seen in this condition.
- You are willing to give permission (informed consent) to be in the study.
- You do not have hearing loss caused by factors like being born early, lack of oxygen, or severe jaundice.
- You do not have hearing loss that is part of a syndrome (like Usher or Waardenburg), and you do not have a cochlear implant in both ears.
- You do not have structural problems in the inner ear or the hearing nerve.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows children with hearing loss caused by changes in specific genes (GJB2 or OTOF). It helps researchers understand how hearing develops over time and how children may do with or without cochlear implants.
This study follows people with hearing loss caused by changes (mutations) in the otoferlin gene to better understand how hearing and hearing-related test results change over time. It may help researchers prepare for future treatments by building a clear picture of the natural course of the condition.
This trial tests a gene therapy called EH002 for people with severe or profound hearing loss due to changes in the OTOF gene. The treatment aims to help the ear hear better by replacing the faulty gene.
This study builds a patient registry and tracks the natural history of hearing loss in people whose genetic test shows changes in the otoferlin (OTOF) gene. It may help researchers understand how hearing symptoms progress over time and improve future treatments.
This trial tests a one-time gene therapy delivered into the ear to improve hearing in people with certain OTOF gene changes. It studies safety and how well the treatment can work, especially in children and infants, as doctors monitor hearing tests for up to 48 weeks.
This trial tests an injection called EHT102 for children who have severe or profound hearing loss due to mutations in the Otoferlin gene. The goal is to see if the treatment can restore or improve hearing.
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