Understanding age-related blood cell changes in health and disease
Part of Blood & lymphatic, Heart & circulation clinical trials.
This study looks at how certain age-related changes in blood cells (called clonal hematopoiesis) affect inflammation and health. It aims to understand why some people with these changes develop health problems like heart disease or blood disorders, while others stay healthy. Depending on your situation, you might join a group that has these changes but no health issues, or a group that has them along with specific conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 60 years old.
- You must have a specific blood test finding (a gene change in your blood cells) or a related blood condition.
- You must not have had a stroke or heart attack in the past (unless you are in the group that had a recent heart attack).
- You must not have a current cancer diagnosis (excluding non-melanoma skin cancer).
- You must not have had surgery in the last 3 months (for some groups).
- You must not be taking immunosuppressive medication or have an autoimmune disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study examines whether certain changes in blood cells are connected to how severe a heart attack is. Researchers will perform heart imaging and blood tests on people who have just had their first heart attack to understand this relationship better.
This study looks at a condition called clonal hematopoiesis (CH), where some blood cells have changes that may affect their health. It aims to prevent, treat, and better understand CH. You may qualify if you are 55 or older and have low blood counts that persist over time.
This study looks at blood cell changes that can affect the immune system. It aims to better understand how these changes relate to immune problems and related diseases, and what might matter for treatment decisions.
This study collects blood samples and health information from people with certain unexplained blood cell changes or those at higher risk for them, to learn how these changes relate to inflammation and heart health.
This study follows adults who have certain blood-cell DNA changes (CHIP or CCUS) to learn how their condition may progress over time. It mainly looks at natural history—what happens in the blood without giving an active treatment.
This study follows people who may have early, unclear blood count problems or certain genetic/immune patterns that can later lead to bone marrow failure or blood cancers. It may help doctors better understand risks over time and guide earlier care.
Hear when a new Clonal Hematopoiesis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.