Comparing two ablation methods for persistent atrial fibrillation
Part of Heart & circulation clinical trials.
This study compares two procedures to treat persistent atrial fibrillation (an irregular heartbeat that lasts more than a week). It looks at whether a newer method (pulsed-field ablation) works better than the standard method (radiofrequency ablation), both combined with a chemical injection to improve treatment success.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have persistent atrial fibrillation (an ongoing irregular heartbeat).
- Your heart's pumping ability is more than 30% (measured by ejection fraction).
- You have mild to moderate heart failure symptoms (NYHA class I-III).
- Your left atrium (upper heart chamber) is smaller than 55 mm on an ultrasound.
- You have not had a prior ablation procedure for atrial fibrillation.
- You are not pregnant, and you do not have severe liver or kidney disease, uncontrolled thyroid issues, or other major health problems that would make participation unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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