Low-dose duloxetine with alpha-lipoic acid for diabetic nerve pain
Treatments studied
Part of Brain & nervous system, Hormones & metabolism, Pain clinical trials.
This trial compares two ways to treat painful diabetic nerve damage: a lower dose of the drug duloxetine combined with a supplement called alpha-lipoic acid, versus a standard dose of duloxetine alone. The goal is to see if the combination works as well or better with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have diabetes.
- You must have nerve pain from diabetes that has lasted at least 3 months and is moderate to severe (score of 4 or higher on a 0-10 pain scale).
- You must not have taken certain medications (antidepressants, anti-seizure drugs, sedatives, antipsychotics, or opioids) in the last 4 weeks.
- You must not have other causes for the pain (such as arthritis or poor circulation) or certain conditions like kidney or liver disease, vitamin B12 deficiency, or active depression.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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