Comparing two drugs to lower brain pressure after head injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This study compares two medicines, mannitol and hypertonic saline, to see which one works better at reducing pressure inside the skull after a severe head injury. The pressure is measured using a simple ultrasound test on the eye, avoiding more invasive methods.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had a severe head injury and are in a coma (Glasgow Coma Scale score between 3 and 8).
- A CT scan of your brain shows signs of the injury.
- An ultrasound of your eye shows increased pressure inside the skull (optic nerve sheath diameter of 5.6 mm or more).
- You can receive the study medicine within 24 hours of your injury.
- You do not have any of the following: penetrating head injury, low blood pressure, previous eye injury or eye surgery, glaucoma or optic nerve problems, both eyes injured, pregnancy, kidney failure requiring dialysis, very high sodium levels in the blood, or you have not already received a similar medicine for this injury.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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