Pemigatinib plus immunotherapy for FGFR2-positive bile duct cancer
Part of Cancer, Digestive system clinical trials.
This study tests a combination of two drugs—pemigatinib (a targeted therapy) and a PD-1 inhibitor (an immunotherapy)—with or without chemotherapy, for people with advanced bile duct cancer that has an FGFR2 fusion or rearrangement. The goal is to see if this combination is more effective than standard treatment, and to find better ways to treat this type of cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 to 80 years old.
- Your cancer must be advanced (unresectable or metastatic) and confirmed as bile duct cancer.
- Your tumor must have an FGFR2 fusion or rearrangement.
- You must not have had prior treatment with an FGFR inhibitor (e.g., pemigatinib).
- Your overall health should be reasonably good (ECOG performance status 0-2).
- Your blood counts and organ function must meet certain minimum levels.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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