New drug alone or with inclisiran for high cholesterol and triglycerides
Treatments studied
Part of Heart & circulation, Hormones & metabolism clinical trials.
This study tests a new investigational drug called MWX203, given alone or with another medicine (inclisiran), to lower both 'bad' cholesterol (LDL) and triglycerides in people with mixed dyslipidemia. The goal is to see if the combination is safe and works better than statins alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been on a stable dose of a statin (like atorvastatin, rosuvastatin, or similar) for at least 4 weeks and plan to keep the same dose.
- Your blood tests show a certain level of LDL ('bad') cholesterol and triglycerides that put you in the moderate-to-high risk category for heart problems.
- You have not had a heart attack, stroke, or open-artery procedure in the past year, and you have no severe heart failure or serious rhythm problems.
- You have not used other non-statin lipid-lowering drugs (like ezetimibe, fibrates, or omega-3s) in the last 4 weeks, and never used PCSK9 inhibitors in the last 6 months.
- You agree to use effective contraception and not to donate sperm or eggs for at least 6 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new medication called SYH2053 to see if it helps lower 'bad' cholesterol more effectively when added to your current statin therapy. It is for patients whose cholesterol is still not at their doctor's target level, and it aims to improve heart health.
This study tests a new medication (MWX205) given as a shot to lower high triglycerides, which are fats in the blood. The purpose is to see if it is safe and how well it works.
This trial tests a new version of inclisiran, a cholesterol-lowering medicine, to see if it is safe and works well. The study compares it to the current version. You may qualify if you have moderately high cholesterol but have never taken cholesterol medications.
This study tests a new injectable medicine called inclisiran for people who are already on many medications and have high cholesterol. It is designed for those who cannot lower their cholesterol enough with statins, especially if they have diabetes or other heart risks.
This study tests a cholesterol-lowering injection (inclisiran) given soon after a heart attack, urgent heart procedure, or stroke. The goal is to see if it helps lower bad cholesterol quickly and safely.
This study tests two newer cholesterol-lowering medications (inclisiran and alirocumab) together in people who've had heart problems or strokes and cannot tolerate standard cholesterol drugs. The goal is to see if this combination safely lowers cholesterol further and reduces future cardiovascular events.
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