Adjusting mavacamten dose based on heart function in hypertrophic cardiomyopathy
Treatments studied
Part of Heart & circulation clinical trials.
This study looks at whether adjusting the dose of mavacamten based on heart function helps people with obstructive hypertrophic cardiomyopathy feel better and have fewer side effects. It is for people who are already on mavacamten and want to see if a personalized dose approach works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with obstructive hypertrophic cardiomyopathy (a heart muscle condition that blocks blood flow out of the heart).
- You have symptoms that limit your daily activity (NYHA class II or III).
- You are already taking the medication mavacamten and have been on the same dose for at least 12 weeks.
- Your heart's pumping function (called LVEF) is 55% or higher.
- You are not taking certain other heart medications (like disopyramide or ranolazine) and do not have severe liver or kidney disease.
- You have not had a serious reaction to mavacamten before, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at adults with a heart condition called obstructive hypertrophic cardiomyopathy. It tracks what happens after they start taking the medicine mavacamten, to learn more about its effects and how it works in real life.
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