Semaglutide with intrauterine device for early endometrial cancer
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial is testing whether a weight-loss medication called semaglutide combined with a hormonal intrauterine device (IUD) can help treat early-stage endometrial cancer or precancerous changes, allowing patients who want to preserve fertility or avoid surgery to do so. The study also includes a structured weight loss program.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with atypical hyperplasia or grade 1 endometrial cancer that has not spread into the muscle wall
- Imaging (MRI) showing the cancer is confined to the inner layer of the uterus
- Desire to keep your uterus for future pregnancy or medical reasons preventing surgery (such as severe obesity)
- BMI of 30 or higher, or 27-29.9 with weight-related health issues
- Willing to participate in a weight loss program with counseling and dietary and physical activity goals
- If you've taken progestin before, you must have a waiting period (from 7 days to 6 months depending on the type)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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