Clin2
NCT07825064Possibly a fitRecruiting

Cevostamab combination after CAR T-cell therapy for multiple myeloma

Multiple Myeloma

Treatments studied

Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.

This trial tests a new drug, cevostamab, combined with two standard medicines (pomalidomide and dexamethasone) for people with multiple myeloma who have already had CAR T-cell therapy. It aims to see if this combination can help control the cancer better.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
45 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have been diagnosed with multiple myeloma.
  • You have had 1 to 4 prior treatments, including CAR T-cell therapy.
  • You have received at least one of each of these types of treatment: a CD38-targeting drug (like daratumumab), a proteasome inhibitor (like bortezomib), and lenalidomide.
  • You are generally able to care for yourself (ECOG performance status 0 or 1).
  • You have measurable disease that can be tracked during the trial.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07555938Recruiting· Phase 3
New drug combination for previously treated multiple myeloma

This trial tests whether a new drug called cevostamab, combined with two existing myeloma drugs (pomalidomide and dexamethasone), works better than standard treatment for people whose myeloma has returned or stopped responding to prior therapy. You would receive this combination to see if it helps control your disease.

Duarte, California
NCT04910568Recruiting· Phase 1
Study of cevostamab for people with returning or hard-to-treat myeloma

This trial tests a new drug called cevostamab for people whose multiple myeloma has come back or stopped responding to treatment. It aims to see if the drug is safe and how well it works.

Duarte, California
NCT05583617Recruiting· Phase 1/Phase 2
Testing multiple treatments for multiple myeloma after prior therapy

This early-phase study tests how safe and effective several treatment approaches are for people with multiple myeloma who have already had other treatments. Depending on your myeloma features and prior care, a study drug combination may be offered to try to control the disease.

Randwick, New South Wales
NCT06121843Recruiting· Phase 1
Study of CAR-T cell therapy in combinations for multiple myeloma

This trial tests a new CAR-T cell therapy (called arlocabtagene autoleucel) combined with other drugs for multiple myeloma that has returned or stopped responding. It aims to find a safe and effective dose while tracking how well the treatment works.

Birmingham, Alabama
NCT06913192Not yet recruiting· Phase 1
Car-t cell therapy after stem cell transplant for multiple myeloma

This trial tests a new treatment that combines a stem cell transplant with special immune cells (called CAR-T cells) to fight multiple myeloma. The goal is to see if this combined approach helps people with newly diagnosed myeloma achieve better control of their disease.

NCT07149857Recruiting· Phase 2
A study of CAR-T therapy for newly diagnosed multiple myeloma

This trial tests a one-time cell therapy called ciltacabtagene autoleucel (a CAR-T treatment) in people who have newly diagnosed multiple myeloma and are not eligible for a stem cell transplant. It aims to see if this treatment is safe and effective as an early therapy.

San Francisco, California

Hear when a new Multiple myeloma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.