Comparing oral ketamine and midazolam for depression
Part of Mental health clinical trials.
This trial tests whether two oral medications, ketamine and midazolam, can help treat major depression when taken by mouth. It aims to compare how well each drug works in reducing depressive symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 or older) with moderate to severe depression or bipolar depression.
- Your symptoms must be severe enough to score at least 20 on a standard depression rating scale (a doctor will check this).
- You cannot have OCD, intellectual disability, or substance dependence (except nicotine).
- You cannot be receiving neuromodulation treatments like ECT or TMS.
- You cannot have active suicidal thoughts with a plan in the last 3 days if you are an outpatient.
- You must not have an abnormal ECG, uncontrolled high blood pressure, or be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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