Ketamine study for depression with reduced pleasure
Treatments studied
Part of Injuries & trauma, Mental health clinical trials.
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- If you have depression: you must have a current diagnosis of major depressive disorder and score high on a depression questionnaire (at least 20).
- If you have depression: you must be off all antidepressant medicines for at least 8 weeks before the study starts.
- You must be between 18 and 65 years old and able to sign informed consent.
- You must not have a history of bipolar disorder or psychosis, and you should not be having active psychotic symptoms.
- You must be able to safely have MRI scans (no MRI contraindications).
- You should not be pregnant or breastfeeding, and you must avoid recreational drugs around the time of scanning.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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