Donor stem cell transplant for stubborn systemic juvenile arthritis
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This study tests a bone marrow transplant (using donor cells) to treat severe systemic juvenile idiopathic arthritis (sJIA) that has not responded to other treatments. The goal is to reset the immune system to stop the disease and its complications, like lung problems or recurrent macrophage activation syndrome.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be under 35 years old.
- Your child must have been diagnosed with systemic juvenile idiopathic arthritis (sJIA) before age 16.
- The arthritis or related symptoms (like fever, rash, or joint damage) must not be improving with standard treatments like biologics or steroids.
- Your child must have had at least one of these: active disease despite treatment, two or more episodes of macrophage activation syndrome in the last 2 years, or lung disease related to sJIA.
- Your child must not have a severe uncontrolled infection, significant heart or kidney problems, active cancer, or be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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