Stem cell infusion for autoimmune diseases
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Immune system & allergy, Skin clinical trials.
This clinical trial is testing if infusions of special stem cells (called mesenchymal stem cells) can help people with certain autoimmune diseases where standard treatments have not worked well enough. It is an early-phase study in Pakistan for adults (and some children for one condition) with rheumatoid arthritis, lupus, systemic sclerosis, ankylosing spondylitis, or dermatomyositis/polymyositis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You or the patient must be at least 18 years old (note: for dermatomyositis/polymyositis, ages 5–50 are allowed).
- You must have one of these autoimmune diseases: rheumatoid arthritis, lupus, systemic sclerosis, ankylosing spondylitis, or dermatomyositis/polymyositis.
- For rheumatoid arthritis: you need to have tested positive for rheumatoid factor or anti-CCP and have had symptoms for between 6 weeks and 5 years.
- For lupus: the disease must be active and not responding well to standard medicines like hydroxychloroquine.
- You must not have an active serious infection (like HIV, hepatitis B or C, or tuberculosis) or untreated infection.
- You must not have had certain prior treatments (like rituximab or other biologic drugs) within specific time frames, and you must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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