Testing added drugs for children with a brain tumor
Treatments studied
Part of Cancer clinical trials.
This study tests whether adding two medicines, 5-fluorouracil (5-FU) and tretinoin (ATRA), to standard treatment helps children with a type of brain tumor called ependymoma. It aims to find safe doses and see if they improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 1 and 21 years old
- You have been diagnosed with a specific type of ependymoma in the back of the brain, known as PFA group
- Your tumor has certain genetic changes (chromosome 1q gain or 6q loss) that make it more likely to come back
- The tumor has not spread to other parts of the brain or spine
- Your kidney, liver, heart, and blood counts are within healthy ranges for your age
- You have not had any prior treatment except surgery and steroids
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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