Clinical trials
Active Surveillance clinical trials
Below are recruiting active surveillance clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06075953RecruitingPhase 2
Testing Active Surveillance for Hormone-Positive DCIS After Surgery
This trial tests whether active surveillance (close monitoring) is a good option for certain patients with hormone-positive DCIS who have positive surgical margins after initial surgery. You would receive no immediate additional treatment—just regular imaging and check-ups.
Berkeley, CaliforniaAges 18 years+ - NCT05948657Recruiting
PSMA PET-CT scan for men on prostate cancer surveillance
This study checks whether a special prostate scan called PSMA PET-CT (along with standard monitoring scans) can help guide care while you are on “active surveillance” instead of immediate treatment. It may help doctors track low-risk prostate cancer changes more accurately over time.
Los Angeles, CaliforniaAges 18 years+ - NCT05918263Recruiting
Exercise to slow prostate cancer in men on active surveillance
This trial tests whether moderate exercise can help keep low-risk prostate cancer from growing in men who are monitoring their cancer instead of treating it right away. It may be especially helpful for men with certain risk factors like obesity or being Black or African American.
Boston, MassachusettsAges 18 years+ - NCT05852041RecruitingEarly Phase 1
PET-MRI scan to find prostate cancer before active surveillance
This early-phase study tests a special PET-MRI scan using rhPSMA-73 to better detect prostate cancer areas in men who would otherwise choose active surveillance. It may help doctors see where (and how much) cancer is present before deciding on treatment.
Chicago, IllinoisAges 18 years+ - NCT05497024Recruiting
Decision aid testing for older men on prostate cancer surveillance
This trial tests an English decision aid (a patient guide) to help older men understand and feel comfortable with “active surveillance” for localized prostate cancer. It also checks how easy to use it is for patients, caregivers, and prostate cancer clinicians.
Houston, TexasAges 65 years+ - NCT05345847Recruiting
Steroid-sparing treatment for immune hepatitis during cancer immunotherapy
This trial studies a way to treat inflammation of the liver (hepatitis) caused by immune cancer medicines (anti-PD-1/PD-L1, sometimes with anti-CTLA-4) without relying on high-dose steroids. It may help reduce steroid side effects while keeping liver inflammation under control.
Calgary, AlbertaAges 18 years+ - NCT04692675Recruiting
MRI study to track prostate cancer in active surveillance patients
This study uses special prostate MRI scans to see how prostate cancer changes over time while you stay on active surveillance. It also looks at prostate tissue to understand your cancer’s genetics, which may help guide future decisions.
Bethesda, MarylandAges 18 years+ - NCT04052048Recruiting
Active surveillance prostate cancer test registry study
This study enrolls men with low-risk prostate cancer who are either staying on active surveillance or planning surgery soon. It uses a new “SNEP assay” test to help monitor prostate cancer over time and may improve how doctors track risk.
Royal Oak, MichiganAges 40–80 - NCT03892993Recruiting
Decision aid for medullary thyroid cancer treatment choices
This study tests a patient-and-caregiver decision guide to help you decide when to start or stop a new cancer drug, join a clinical trial, or continue active surveillance. It aims to make tough choices feel clearer and more supported.
Houston, TexasAges 18 years+ - NCT03933670RecruitingPhase 2
MRI scan with special sugar to monitor prostate cancer on surveillance
This study uses a special MRI scan using “hyperpolarized” labeled pyruvate (a sugar-like substance) to see how prostate cancer may be behaving in people who are on active surveillance. It may help researchers monitor cancer without immediate treatment, by spotting changes earlier.
San Francisco, CaliforniaAges 18 years+ - NCT03769766RecruitingPhase 3
Curcumin to help keep low-risk prostate cancer from worsening
This study tests whether curcumin (a supplement made from turmeric) can prevent low-risk prostate cancer from progressing while you stay on active surveillance. If you qualify, you would take curcumin and be monitored closely with regular checkups.
Dallas, TexasAges 40–89 - NCT03648359Enrolling by invitation
MRI scans to monitor low-risk prostate cancer in active surveillance
This trial uses special MRI scans to help track low-risk prostate cancer while you stay on active surveillance (meaning no immediate treatment). It may help your care team better understand changes in the cancer over time.
HerlevAges 18–75 - NCT03594630RecruitingEarly Phase 1
Watchful waiting then chemotherapy before surgery for rectal cancer
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Houston, TexasAges 18 years+ - NCT03067181RecruitingPhase 3
Active surveillance and chemotherapy for germ cell tumors
This study looks at how to manage germ cell tumors in children and young adults using careful monitoring for some patients and chemotherapy for others. It aims to see whether these approaches can control the cancer while avoiding unnecessary treatment when possible.
Birmingham, AlabamaAges Any age - NCT02526797Enrolling by invitation
MRI scan study for men on active surveillance
This trial tests how a special MRI scan (with multiple measurements) may help men with low-risk prostate cancer who are monitoring it closely instead of treating right away. It may help doctors better understand the cancer’s status during active surveillance.
HerlevAges 18–75 - NCT01511393Enrolling by invitation
Tracking people with thyroid cancer to learn its course
This study follows adults who have medullary thyroid cancer (MTC) to learn how the cancer behaves over time. It may help by improving future care and follow-up strategies for people with MTC.
Morgantown, West VirginiaAges 18 years+ - NCT00414115Recruiting
Studying side effects of medicines in children
This study follows children who take medicines to better understand what causes side effects. It also looks at family history and genetics to see who may be more likely to have an adverse reaction, and it checks findings using adults.
Vancouver, British ColumbiaAges Any age - NCT00756665Recruiting
Study of careful monitoring for prostate cancer
This study follows people with early-stage prostate cancer who choose active surveillance instead of immediate treatment. It aims to see how monitoring with repeat prostate biopsies and follow-up works over time.
San Francisco, CaliforniaAges 21 years+ - NCT04876781Recruiting
Track safety of Xeljanz XR in Korea
This study collects real-world safety information about Xeljanz XR after it has been approved. It includes people with certain immune-related joint diseases and checks for side effects in everyday use.
SeoulAges 18 years+ - NCT04790253Recruiting
Check brain radiation timing or frequent MRI scans for SCLC
This study compares two ways to follow and treat small-cell lung cancer in the brain: preventive brain radiation versus close monitoring with MRI scans and treatment only if needed. It may help people avoid unnecessary brain treatment or choose the safer timing strategy.
GrazAges 18 years+ - NCT06073873Recruiting
Safety study of ozanimod for ulcerative colitis in Korea
This study is checking the safety of ozanimod, a daily pill, for people with moderate to severe active ulcerative colitis. It looks at how well patients tolerate the medicine in real-world use in Korea.
SeoulAges 19 years+
Hear when a new Active Surveillance trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for active surveillance?
- Yes. Clin2 currently lists 69 recruiting active surveillance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a active surveillance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a active surveillance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.