Clinical trials
Active Surveillance clinical trials
Below are recruiting active surveillance clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05363657Recruiting
Registry study for kidney tumor treatment choices
This study is a registry that collects information on how people with localized kidney tumors are treated (either active treatment or watchful waiting). It may help doctors better understand which approaches work best for different patients.
Los Angeles, CaliforniaAges 18 years+ - NCT04549688Recruiting
Active surveillance with focused ultrasound for prostate cancer
This trial studies whether a high-intensity focused ultrasound treatment can help people with localized prostate cancer while still avoiding traditional full-dose treatment for some patients. It may be an option for certain intermediate-risk cases where the cancer is confined to the prostate.
Tønsberg, VestfoldAges 18–80 - NCT05221398Recruiting
Immunotherapy after liver cancer surgery
This trial tests whether giving immunotherapy after surgery to remove liver cancer can help lower the risk of the cancer coming back. It may be an option for people who have certain risk factors for recurrence.
Nanning, GuangxiAges 18–75 - NCT04886635Recruiting
Surgery timing after chemoradiation for esophageal cancer
This study looks at whether having surgery at the right time after chemoradiation improves outcomes for people with esophageal cancer. You might qualify if you have had (or are planning) chemoradiation and then are going to have surgery to remove the tumor.
Rotterdam, South HollandAges 18 years+ - NCT07848152Recruiting
Monitoring new heart devices
This study follows patients who receive a special new device for a heart condition, either to close a small hole in the heart or to repair a leaky heart valve. The goal is to see how safe and effective these devices are over time.
Lanzhou, GansuAges 18 years+ - NCT07829081Recruiting
Watch-and-wait after immunotherapy for early-stage GI cancers
This study looks at whether some patients with early-stage stomach, colon, or rectal cancers that are mismatch repair-deficient (a genetic feature making them more likely to respond to immunotherapy) can safely avoid surgery and instead be monitored closely after treatment with immunotherapy. It aims to confirm if this watch-and-wait approach is as effective and helps patients avoid major operations.
BaselAges 18 years+ - NCT07730645Recruiting
Argon plasma treatment versus monitoring for moderate cervical precancer
This trial compares two ways of managing CIN 2, a moderate precancerous change on the cervix. One option is a new procedure that uses argon plasma (a type of energized gas) to treat the area; the other is careful monitoring without immediate treatment, to see if one works better at clearing the abnormal cells.
Tübingen, Baden-WurttembergAges 18–40 - NCT07722741RecruitingPhase 2
Vaccine to prevent liver cancer return after surgery
This trial tests a personalized vaccine plus a booster (IL-12) to see if it can stop liver cancer from coming back after surgery. It compares the vaccine to just watching and waiting.
Atlanta, GeorgiaAges 18 years+ - NCT07547163Recruiting
Patient feedback on low-grade brain tumor treatment
This study asks patients with a specific type of low-grade brain tumor (IDH mutant grade 2 glioma) to share their experiences and quality of life while receiving a treatment called vorasidenib, with or without radiation. Your feedback helps doctors understand how well the treatment works from your perspective.
MilanAges 18 years+ - NCT06785441Recruiting
Decision aid for older men considering active surveillance for prostate cancer
This study tests a decision aid to help men aged 65 and older with early-stage prostate cancer decide whether to choose active surveillance (monitoring the cancer instead of immediate treatment). The goal is to see if the tool helps men and their care partners make a more informed choice.
Houston, TexasAges 65 years+ - NCT07285057RecruitingPhase 2
New PET scan for men with low-risk prostate cancer on active surveillance
This trial tests a new imaging test called rhPSMA-7.3 (18F) PET/CT to see if it can better detect prostate cancer in men who are on active surveillance because their cancer is considered low-risk or favorable intermediate-risk. You would also get an MRI and a biopsy as part of the study.
New York, New YorkAges 18 years+ - NCT07168616Recruiting
PSMA PET imaging for active surveillance in low-risk prostate cancer
This study uses a special imaging test (PSMA PET/CT) to better see if men with low-risk prostate cancer are good candidates for active surveillance (monitoring instead of immediate treatment). It helps doctors decide if watching the cancer closely is safe.
Istanbul, TurkeyAges 18 years+ - NCT06866041Recruiting
Prostate cancer markers and imaging for low-risk patients on active surveillance
This trial looks for new markers and advanced scans to better predict which low-risk prostate cancers might grow. If you have low-risk prostate cancer and are managing it with active surveillance, researchers want to see if PSMA-PET scans and tissue markers can give earlier warning of progression.
Milan, ItalyAges 45–80 - NCT06998342RecruitingPhase 2
Mohs surgery plus short radiation for head and neck skin cancer
This trial studies a combination of Mohs surgery and a short course of radiation therapy for people with squamous cell skin cancer of the head and neck. The goal is to see if this approach is effective with fewer side effects.
Burlington, VermontAges 18 years+ - NCT06974370RecruitingPhase 2
Avoiding brain radiation when chemo or other drugs work
This trial tests whether some people with brain metastases from solid tumors can safely skip radiation if their cancer drugs (like targeted therapy, immunotherapy, or certain chemotherapies) shrink the brain tumors. You will get MRI scans to see if the drugs are working.
Burlington, VermontAges 18 years+ - NCT06981637RecruitingPhase 2
PLD vs. observation for advanced soft tissue sarcoma
This trial tests whether a type of chemotherapy called pegylated liposomal doxorubicin (PLD) can help keep advanced soft tissue sarcoma from growing after successful first treatment with standard anthracycline-based chemo. You may be eligible if you've completed 4-8 cycles of that initial chemo and your disease is controlled (shrank or stable).
Kaohsiung CityAges 18 years+ - NCT06914245Recruiting
Personalized help for bowel symptoms after rectal cancer treatment
This trial studies how to improve bowel symptoms in people treated for rectal cancer. It tests personalized care plans and looks at different factors that may contribute to bowel problems after surgery or a watch-and-wait approach.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06733350RecruitingPhase 4
Testosterone therapy for low testosterone in men with low-risk prostate cancer
This study tests whether testosterone replacement therapy can safely improve low testosterone levels in men with low-risk prostate cancer who are not getting immediate treatment. It aims to help men feel better without worsening their cancer.
Buffalo, New YorkAges 18 years+ - NCT06028555Recruiting
Study on safety of estetrol birth control pills
This study is tracking the safety of a new type of birth control pill containing estetrol (E4) and drospirenone (DRSP) compared to a standard pill. It will help doctors understand if this new option is safe for women who start using it.
Berlin, State of BerlinAges Any age - NCT06186271Recruiting
Safety of Estetrol Birth Control Pill Study
This study checks the safety of a newer birth control pill (E4/DRSP) compared to other common pills. It is for women who are just starting one of these pills.
Berlin, State of BerlinAges Any age - NCT06358469Recruiting
Vulvar cancer surgery guided by HPV and p53 testing
This trial is for people with early-stage vulvar cancer that can be surgically removed. It looks at the cancer's HPV and p53 status to decide how much tissue to remove, aiming to reduce side effects while keeping the cancer away.
Kelowna, British ColumbiaAges 18 years+ - NCT06280781Recruiting
Long-term active surveillance for prostate cancer
This trial studies whether men with low-risk prostate cancer can safely avoid treatment by closely monitoring their cancer over many years. It tests a new approach to see if it is better than the current standard of care.
Ascot, BerkshireAges 18 years+ - NCT06261190Enrolling by invitation
Active monitoring for low-risk thyroid cancer
This trial tests whether it is safe to avoid immediate surgery and instead monitor small thyroid cancers that are considered low-risk. If you join, doctors will check regularly to make sure the cancer does not grow or spread.
Goyang-siAges 18 years+ - NCT06212323Recruiting
Monitoring high-risk smoldering myeloma over time
This trial watches people with a high-risk form of smoldering myeloma (an early, inactive stage of bone marrow cancer) to learn more about how it changes. It may help doctors know who needs treatment later.
Salt Lake City, UtahAges 18 years+
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Common questions
- Are there clinical trials for active surveillance?
- Yes. Clin2 currently lists 69 recruiting active surveillance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a active surveillance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a active surveillance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.