Clinical trials
Active Surveillance clinical trials
Below are recruiting active surveillance clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06981637RecruitingPhase 2
PLD vs. observation for advanced soft tissue sarcoma
This trial tests whether a type of chemotherapy called pegylated liposomal doxorubicin (PLD) can help keep advanced soft tissue sarcoma from growing after successful first treatment with standard anthracycline-based chemo. You may be eligible if you've completed 4-8 cycles of that initial chemo and your disease is controlled (shrank or stable).
Kaohsiung CityAges 18 years+ - NCT06866041Recruiting
Prostate cancer markers and imaging for low-risk patients on active surveillance
This trial looks for new markers and advanced scans to better predict which low-risk prostate cancers might grow. If you have low-risk prostate cancer and are managing it with active surveillance, researchers want to see if PSMA-PET scans and tissue markers can give earlier warning of progression.
Milan, ItalyAges 45–80 - NCT06028555Recruiting
Study on safety of estetrol birth control pills
This study is tracking the safety of a new type of birth control pill containing estetrol (E4) and drospirenone (DRSP) compared to a standard pill. It will help doctors understand if this new option is safe for women who start using it.
Berlin, State of BerlinAges Any age - NCT06186271Recruiting
Safety of Estetrol Birth Control Pill Study
This study checks the safety of a newer birth control pill (E4/DRSP) compared to other common pills. It is for women who are just starting one of these pills.
Berlin, State of BerlinAges Any age - NCT05345847Recruiting
Steroid-sparing treatment for immune hepatitis during cancer immunotherapy
This trial studies a way to treat inflammation of the liver (hepatitis) caused by immune cancer medicines (anti-PD-1/PD-L1, sometimes with anti-CTLA-4) without relying on high-dose steroids. It may help reduce steroid side effects while keeping liver inflammation under control.
Calgary, AlbertaAges 18 years+ - NCT06075953RecruitingPhase 2
Testing Active Surveillance for Hormone-Positive DCIS After Surgery
This trial tests whether active surveillance (close monitoring) is a good option for certain patients with hormone-positive DCIS who have positive surgical margins after initial surgery. You would receive no immediate additional treatment—just regular imaging and check-ups.
Berkeley, CaliforniaAges 18 years+ - NCT03067181RecruitingPhase 3
Active surveillance and chemotherapy for germ cell tumors
This study looks at how to manage germ cell tumors in children and young adults using careful monitoring for some patients and chemotherapy for others. It aims to see whether these approaches can control the cancer while avoiding unnecessary treatment when possible.
Birmingham, AlabamaAges Any age - NCT03594630RecruitingEarly Phase 1
Watchful waiting then chemotherapy before surgery for rectal cancer
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Houston, TexasAges 18 years+ - NCT03769766RecruitingPhase 3
Curcumin to help keep low-risk prostate cancer from worsening
This study tests whether curcumin (a supplement made from turmeric) can prevent low-risk prostate cancer from progressing while you stay on active surveillance. If you qualify, you would take curcumin and be monitored closely with regular checkups.
Dallas, TexasAges 40–89 - NCT03803553RecruitingPhase 3
Testing blood tumor DNA treatment after stage III colon surgery
This trial studies how to find tiny hidden cancer cells after stage III colon cancer surgery using a blood test. If the blood test shows tumor DNA, you may get additional treatment to lower the chance of cancer coming back.
Boston, MassachusettsAges 18 years+ - NCT03892993Recruiting
Decision aid for medullary thyroid cancer treatment choices
This study tests a patient-and-caregiver decision guide to help you decide when to start or stop a new cancer drug, join a clinical trial, or continue active surveillance. It aims to make tough choices feel clearer and more supported.
Houston, TexasAges 18 years+ - NCT03933670RecruitingPhase 2
MRI scan with special sugar to monitor prostate cancer on surveillance
This study uses a special MRI scan using “hyperpolarized” labeled pyruvate (a sugar-like substance) to see how prostate cancer may be behaving in people who are on active surveillance. It may help researchers monitor cancer without immediate treatment, by spotting changes earlier.
San Francisco, CaliforniaAges 18 years+ - NCT04135664RecruitingPhase 3
Compare surgery vs chemoradiation for early throat cancer
This study compares two ways to treat a type of esophagus cancer: surgical removal (esophagectomy) versus chemoradiation (chemo plus radiation). It is for people with early-stage findings where scans suggest no lymph node spread.
Nanchang, JiangxiAges 18–75 - NCT04146077Recruiting
Active monitoring for low-risk prostate cancer
This study tests whether watching low-risk prostate cancer closely (instead of treating right away) is safe. It may help some people avoid early treatments and their side effects while still keeping a close eye on the cancer.
MoscowAges 50–75 - NCT04549688Recruiting
Active surveillance with focused ultrasound for prostate cancer
This trial studies whether a high-intensity focused ultrasound treatment can help people with localized prostate cancer while still avoiding traditional full-dose treatment for some patients. It may be an option for certain intermediate-risk cases where the cancer is confined to the prostate.
Tønsberg, VestfoldAges 18–80 - NCT04692675Recruiting
MRI study to track prostate cancer in active surveillance patients
This study uses special prostate MRI scans to see how prostate cancer changes over time while you stay on active surveillance. It also looks at prostate tissue to understand your cancer’s genetics, which may help guide future decisions.
Bethesda, MarylandAges 18 years+ - NCT04886635Recruiting
Surgery timing after chemoradiation for esophageal cancer
This study looks at whether having surgery at the right time after chemoradiation improves outcomes for people with esophageal cancer. You might qualify if you have had (or are planning) chemoradiation and then are going to have surgery to remove the tumor.
Rotterdam, South HollandAges 18 years+ - NCT05363657Recruiting
Registry study for kidney tumor treatment choices
This study is a registry that collects information on how people with localized kidney tumors are treated (either active treatment or watchful waiting). It may help doctors better understand which approaches work best for different patients.
Los Angeles, CaliforniaAges 18 years+ - NCT05497024Recruiting
Decision aid testing for older men on prostate cancer surveillance
This trial tests an English decision aid (a patient guide) to help older men understand and feel comfortable with “active surveillance” for localized prostate cancer. It also checks how easy to use it is for patients, caregivers, and prostate cancer clinicians.
Houston, TexasAges 65 years+ - NCT05558241Recruiting
Ultrasound test for men on active surveillance for prostate cancer
This study checks whether a new, small ultrasound approach can help confirm prostate cancer during active surveillance. It may help by providing a safer or more targeted way to decide whether ongoing monitoring is still enough.
Los Angeles, CaliforniaAges 18 years+ - NCT05948657Recruiting
PSMA PET-CT scan for men on prostate cancer surveillance
This study checks whether a special prostate scan called PSMA PET-CT (along with standard monitoring scans) can help guide care while you are on “active surveillance” instead of immediate treatment. It may help doctors track low-risk prostate cancer changes more accurately over time.
Los Angeles, CaliforniaAges 18 years+ - NCT06212323Recruiting
Monitoring high-risk smoldering myeloma over time
This trial watches people with a high-risk form of smoldering myeloma (an early, inactive stage of bone marrow cancer) to learn more about how it changes. It may help doctors know who needs treatment later.
Salt Lake City, UtahAges 18 years+ - NCT06280781Recruiting
Long-term active surveillance for prostate cancer
This trial studies whether men with low-risk prostate cancer can safely avoid treatment by closely monitoring their cancer over many years. It tests a new approach to see if it is better than the current standard of care.
Ascot, BerkshireAges 18 years+ - NCT05918263Recruiting
Exercise to slow prostate cancer in men on active surveillance
This trial tests whether moderate exercise can help keep low-risk prostate cancer from growing in men who are monitoring their cancer instead of treating it right away. It may be especially helpful for men with certain risk factors like obesity or being Black or African American.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for active surveillance?
- Yes. Clin2 currently lists 67 recruiting active surveillance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a active surveillance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a active surveillance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.