Clinical trials
Acute Treatment of Migraine clinical trials
Below are recruiting acute treatment of migraine clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07609914RecruitingPhase 4
Safety study of an extra dose of rimegepant for migraine
This study tests whether taking an additional dose of rimegepant (a migraine medicine you may already use) is safe and helpful for adults with migraine. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist—a type of medicine that blocks a protein involved in migraine pain.
Canoga Park, CaliforniaAges 18 years+ - NCT07645924RecruitingPhase 3
Elismetrep for fast relief of migraine attacks
This trial tests a new oral medication called elismetrep (K-304) for quickly stopping migraine pain and other symptoms. If you have regular migraines, this could offer a new option that works fast when a migraine starts.
Birmingham, AlabamaAges 18–75 - NCT04649242RecruitingPhase 3
Migraine pain relief study for kids and teens
This trial studies a medicine for stopping a migraine attack in children and teens. It may help families understand which treatment works best during acute (during-attack) migraine pain.
Birmingham, AlabamaAges 6–17 - NCT07674654RecruitingPhase 3
Long-term safety of elismetrep for acute migraine
This study tests the long-term safety of elismetrep (K-304), a medication for acute migraine attacks. It is for people who have already completed a previous elismetrep study and want to continue treatment under close medical supervision.
Birmingham, AlabamaAges 18 years+ - NCT04743141RecruitingPhase 3
Long-term migraine medicine study for kids with migraine attacks
This Phase 3 study checks the long-term safety of rimegepant, a migraine treatment, in children and teens. You might join if your child has had migraine for at least 6 months and still gets a certain number of moderate-to-severe migraine attacks.
Scottsdale, ArizonaAges 6–17 - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT06995729RecruitingPhase 1
Testing zavegepant nasal spray in children with migraines
This trial tests whether the medicine zavegepant (given as a nasal spray) is safe and works well for children aged 6 to 11 who have a history of migraines. If your child gets migraines, this study may help find a new treatment option.
Little Rock, ArkansasAges 6–11 - NCT07646613RecruitingPhase 2
Testing an inhaled migraine medicine for quick relief
This study tests a new inhaled powder form of a migraine medication called dihydroergotamine (DHE) to see if it safely and effectively stops migraine attacks. If you have frequent migraines, this trial might offer you a new treatment option to try.
Walnut Creek, CaliforniaAges 18–65 - NCT06401642RecruitingPhase 4
Zavegepant for acute migraine with CGRP preventives
This study tests how well a new acute migraine medicine, zavegepant, works and is tolerated in people who are already taking a CGRP-targeting preventive medication. It may help you find an effective treatment when you get a migraine attack.
Phoenix, ArizonaAges 18 years+ - NCT05127954Enrolling by invitationPhase 3
Long-term migraine tablet study for kids and teens ages 6–17
This study follows kids and teens who already took part in an earlier migraine medication study to check long-term safety and comfort with oral ubrogepant tablets. It may help families understand whether this migraine tablet is safe to keep using over time.
Huntsville, AlabamaAges 6–17 - NCT05125302RecruitingPhase 3
Ubrogepant for acute migraine relief in kids and teens
This study tests how safe ubrogepant is and whether it helps treat an individual migraine attack in children and teens. It focuses on measuring side effects and whether headaches improve 2 hours after taking the study medicine.
Huntsville, AlabamaAges 6–17 - NCT07685769RecruitingPhase 4
Rimegepant safety study for adults with migraine in India
This study tests if the medicine rimegepant is safe for people with migraine. You may be able to join if you have had migraine for at least a year, have 4–14 migraine days per month, and have not had good results with other migraine medicines called triptans.
Bangalore, KarnatakaAges 18 years+ - NCT04151472RecruitingPhase 3
Idebenone to prevent episodic migraine attacks
This trial tests idebenone, a preventive medicine, to see if it can reduce how often migraine attacks happen. It mainly focuses on people with episodic migraine who have regular attacks and are not already using other migraine prevention treatments.
Hangzhou, ZhejiangAges 18–65 - NCT07671703Recruiting
Physiotherapy for migraine relief
This trial tests whether a combination of physical therapy techniques can reduce migraine symptoms. It may help people whose migraines are not caused by other conditions.
Osnabrück, Low SaxonyAges 18–70 - NCT07304518RecruitingPhase 2
PRT-064040 nasal spray for migraine in adults
This trial tests a new nasal spray, PRT-064040, to see if it can help treat migraine attacks. It is for adults who have had migraines for at least a year and get 2 to 8 moderate to severe migraines per month.
Beijing, Beijing MunicipalityAges 18–75 - NCT06735768Recruiting
Daily magnetic brain stimulation to prevent migraines
This study tests a type of magnetic brain stimulation (repetitive TMS) given daily at home to prevent migraines. It may be an option if your migraine medications aren't enough or you want a non-drug treatment.
Vienna, State of ViennaAges 18–65 - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT06248671RecruitingPhase 2
Atorvastatin for preventing migraine attacks
This trial tests whether a daily dose of atorvastatin (a common cholesterol medicine) can prevent migraine attacks in people with episodic migraine. You would keep a headache diary and be randomly assigned to take atorvastatin or a placebo for about 3 months.
BergenAges 18–65 - NCT06485336RecruitingPhase 2
Atorvastatin for prevention of chronic migraine
This trial tests whether the cholesterol drug atorvastatin can reduce the number of migraine days in people with chronic migraine (15 or more headache days per month, including at least 8 migraine days). If you have frequent migraines and haven't tried statins before, this study may offer a new preventive option.
BergenAges 18–65 - NCT06848166RecruitingEarly Phase 1
Middle meningeal artery embolization for resistant chronic migraine
This study tests a procedure called 'middle meningeal artery embolization' using a special glue-like material (SQUID) to treat chronic migraine that hasn't responded to other treatments. The goal is to see if blocking blood flow to the membrane around the brain can reduce migraine attacks.
Bishkek, BishkekAges 35–59 - NCT07301008RecruitingPhase 4
Rimegepant to prevent predictable trigger-induced migraines
This trial tests whether a medication called rimegepant can prevent migraines when you take it before a known trigger (like exercise or stress). It is for people who get migraines often and can predict when one might happen.
McLean, VirginiaAges 18 years+ - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+
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Acute Treatment of Migraine trials by city
Studies with a site in or near these metro areas.
Acute Treatment of Migraine trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for acute treatment of migraine?
- Yes. Clin2 currently lists 22 recruiting acute treatment of migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute treatment of migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute treatment of migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.