Clinical trials
Addiction, Substance clinical trials
Below are recruiting addiction, substance clinical trials, each written for real people, not researchers. We’re tracking 37 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT06899308Recruiting
Health check for university students
This study checks the health of students at two universities in Germany. It uses online surveys and interviews to monitor well-being over time.
BremenAges 18 years+ - NCT06880705Recruiting
Trans-Led Care Study for alcohol and drug support
This study is testing a program designed by and for transgender adults to help with alcohol or drug use problems. It looks at whether a supportive, community-based approach can improve health and well-being.
Chicago, IllinoisAges 18 years+ - NCT05854667RecruitingPhase 2
High-dose lisdexamfetamine with rewards for meth use changes
This Phase 2 study tests high-dose lisdexamfetamine (a prescription stimulant) to help people reduce or stop methamphetamine use. It also uses “contingency management” (rewards tied to meeting goals) to encourage treatment participation and lower use.
Vancouver, British ColumbiaAges 18–55 - NCT04599270Recruiting
Preventing risky drinking in vulnerable teens
This study tests a program meant to reduce addictive behaviors in teens who may be at higher risk. It uses online activities and support, and it may help you build safer habits before problems grow.
BrestAges 14–17 - NCT06973512Recruiting
Brain stimulation for severe addiction
This trial tests a new brain stimulation approach for people with severe addiction that hasn't gotten better with other treatments. It uses deep brain stimulation guided by brain mapping to try to reduce cravings and help you stay abstinent.
Toronto, OntarioAges 25–65 - NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT07193914Recruiting
Program for people with addiction and trauma
This trial tests a program called ECCCLORE to help people who struggle with both addiction and trauma. It aims to see if the program can improve their well-being.
Nîmes, NîmesAges 18 years+ - NCT06076512Recruiting
Pain clinic safety trial for adults with chronic pain
This trial is testing whether a pain clinic can improve public health safety for adults who have chronic pain and also face social or emotional challenges. It aims to see if this kind of care helps people feel better and avoids opioid-related harms.
Surrey, British ColumbiaAges 20–99 - NCT06550167Recruiting
Nano PSO for brain protection in substance users
This trial tests whether a supplement called Nano PSO can help protect the brain in people who have used methamphetamines, cocaine, and cannabis for at least three years. It looks at effects during the withdrawal period for men currently in residential treatment.
Guadalajara, JaliscoAges 18–50 - NCT06675539Recruiting
Testing a tool to predict alcohol withdrawal severity in French speakers
This study tests a French version of a questionnaire (PAWSS) that helps doctors predict how severe alcohol withdrawal might be. It is for people aged 18 to 60 who are dependent on alcohol and planning a supervised detox or being hospitalized for another reason.
ÉtampesAges 18–60 - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT06413979Recruiting
Family support program for teens with substance use and mood or anxiety issues
This trial offers a family support program for teens with both substance use and internalizing problems like depression or anxiety. The goal is to help you and your caregiver work together to manage symptoms and improve well-being.
Jacksonville, FloridaAges 13–21 - NCT05964010Recruiting
Parent-and-teen program for teen health visits
This trial offers a structured support program for teenagers and their primary caregiver during a primary care visit. It may help by testing an approach that connects youth and families with resources and support starting at the clinic visit.
New York, New YorkAges 12–17 - NCT05563363Recruiting
Home-based treatment for severe addiction problems
This trial tests a home-based treatment approach for adults with severe substance use problems. It may help you and your care team manage addiction with structured support while you stay at home.
GenevaAges 18 years+ - NCT04732676Recruiting
Smartphone app to help manage cravings and addiction triggers
This study tests whether a smartphone app can help you manage cravings and personal triggers that lead to substance use or addictive behaviors. It is designed for people who are seeking addiction support and have at least a month before starting treatment.
BordeauxAges 18 years+ - NCT05489068Recruiting
Motivational interviewing approach for people starting addiction treatment
This study compares two ways of having conversations when you begin outpatient addiction treatment. It tests whether a motivational interviewing style at intake improves your engagement and involvement in your care.
Albuquerque, New MexicoAges 18 years+ - NCT06103370Recruiting
HIV prevention via telemedicine and peer networks
This study tests how well a program combining telemedicine (virtual doctor visits) and peer support can help prevent HIV among people who inject drugs. You'd get trained, attend weekly group sessions, and invite a friend or partner to also take part.
Baltimore, MarylandAges 18 years+ - NCT07178158Recruiting
Extra education via app for addiction treatment
This trial tests a smartphone app called NIPA that provides extra education and support for people already taking medication for opioid or stimulant use disorder. It aims to improve addiction treatment by helping you learn more and stay on track.
Richmond, VirginiaAges 18–65 - NCT06370481Recruiting
HIV and addiction training program for Alabama clinics
This study tests a program to help people living with HIV in Alabama who also struggle with opioid or stimulant use. It takes place at your HIV clinic and checks whether a new approach to addiction care can improve your health.
Birmingham, AlabamaAges 18 years+ - NCT07595614Recruiting
Weekly Writing to Track Recovery Progress in Substance Use
This study asks men in residential treatment for substance use to write weekly reflections about their recovery. Researchers will analyze these writings to better understand how people progress through treatment and improve how clinicians support recovery.
Potrerillos, JaliscoAges 18 years+ - NCT07210268Recruiting
Brain stimulation for nicotine addiction treatment
This trial tests a new method called temporal interference to stimulate the brain and help people who vape nicotine reduce their addiction. It aims to see if this non-invasive approach can make it easier to quit.
Bloomington, IndianaAges 21–50 - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+
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Common questions
- Are there clinical trials for addiction, substance?
- Yes. Clin2 currently lists 37 recruiting addiction, substance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a addiction, substance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a addiction, substance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.