Advanced or Metastatic Breast Cancer clinical trials

TIL therapy for advanced melanoma

This trial tests a new cell therapy made from your own tumor-fighting cells (TILs) for advanced melanoma that hasn't responded to other treatments. It aims to shrink tumors by re-infusing these boosted cells back into your body.

Lorlatinib and high cholesterol in ALK+ lung cancer

This study looks at how the drug Lorlatinib affects cholesterol levels in people with ALK-positive non-small cell lung cancer. It aims to understand and manage these side effects better.

Trastuzumab and Chemo Before Surgery for HER2-Positive DCIS

This trial tests giving trastuzumab (a targeted drug) plus a chemotherapy drug called a taxane before surgery for women with HER2-positive ductal carcinoma in situ (DCIS), an early form of breast cancer. The goal is to see if this combination can shrink or eliminate the cancer before surgery.

Adebrelimab plus apatinib after chemoradiation for limited-stage SCLC

This trial tests whether adding two drugs (adebrelimab and apatinib) after standard chemoradiation can help prevent cancer from coming back in people with limited-stage small cell lung cancer. It is for patients whose cancer did not grow after chemoradiation.

New drug vs. afatinib for EGFR-mutant lung cancer

This trial compares a new drug (FHND9041) to a standard targeted therapy (afatinib) for people with advanced lung cancer that has a specific EGFR mutation. It aims to see if the new drug works better or has fewer side effects.

INK cells after chemoradiation for small cell lung cancer

This trial tests whether adding a special immune cell called iNK cells after standard chemoradiation can help keep small cell lung cancer from coming back.

Testing cadonilimab with chemo and radiation for advanced esophageal cancer

This trial tests a new drug (cadonilimab) combined with standard chemotherapy and radiation for people with advanced esophageal squamous cell carcinoma that cannot be surgically removed. The goal is to see if this combination works better than current treatments.

Social needs app for cancer patients having surgery

This study tests a mobile app called Carealth that helps cancer patients address social needs like housing, food, or transportation. It is for patients who are having surgery with an overnight hospital stay and want to see if the app can improve their care.

Genetics and inflammation in prostate cancer stage

This study looks at the connection between genetics, inflammation, and prostate cancer stage. It aims to find markers that may help predict how aggressive the cancer is. You may be eligible if you are newly suspected of having prostate cancer and have not yet started treatment.

Human microbiome study after pancreatic surgery

This study looks at how tiny organisms in your gut (the microbiome) affect recovery after surgery for pancreatic cancer or related growths. It may help doctors understand how to improve outcomes for future patients.

Lung cancer screening follow-up study

This study is testing whether a centralized support program helps people get regular lung cancer screening. If you are at risk for lung cancer and have had a screening CT scan at one of the participating health centers, this study may help improve care.

Testing LIT-00814 tablets for advanced solid tumors

This trial tests an experimental oral tablet (LIT-00814) for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and to find the best dose.

Skin protectant for moisture damage in hospitals

This trial tests a new skin protectant lotion for people in the hospital with skin damage from moisture (like urine or stool). It aims to see if the lotion helps heal these wounds better than current care.

Telehealth education to help people with COPD after a hospital stay

This study tests whether a telehealth (video/phone) education program can help people with COPD better manage their health after a hospital flare-up. It may reduce the chance of needing to return to the hospital soon after discharge.

Testing ZV0203 for HER2-positive advanced solid tumors

This Phase 1 study tests ZV0203, a new investigational treatment, in people with HER2-positive advanced or metastatic solid tumors that cannot be removed and have not responded to standard treatment. The goal is to find a safe dose and see how the disease responds.

Test cemiplimab plus chemo before treatment for head and neck cancer

This Phase 1 trial tests cemiplimab (an immune system medicine) given with “induction” chemotherapy before the main treatment for locally advanced squamous cell head and neck cancer. It’s designed to see how well this treatment is tolerated and to learn about immune responses that may help future patients.

Cervical scan test to find high-risk abnormal cervix cells

This study checks whether an advanced cervical scanning test (LuViva) can better identify people who may have serious precancer or early cancer of the cervix. You may be asked to have the scan around the time you are already scheduled for a colposcopy because your screening results were concerning.

CBT programs for anxiety and coping in cervical cancer

This study tests two structured talk-therapy programs (cognitive-behavioral therapy) to help people with cervical cancer manage anxiety, depression symptoms, and unhelpful coping skills. It also looks at the role of a main caregiver during care planning and support.

PET/CT scan study for high-risk or returning prostate cancer

This trial studies how a special PET/CT scan (using 18F-DCFPyL) helps evaluate prostate cancer that is either high-risk at diagnosis or has come back based on PSA blood tests. It may help your care team better stage (map) the cancer and guide next steps.

Study of data analytics for people with genetic conditions

This is an observational study that collects health and family history information to see how advanced data analysis can help people with genetic conditions. It may involve website forms, optional conversations, and sometimes an NIH visit, depending on your situation.

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

VNS Algorithm for Advanced Dosing

Testing Calderasib for advanced solid tumors with KRAS G12C mutation

This trial tests a new drug, Calderasib (MK-1084), for people with advanced solid tumors that have a specific KRAS G12C mutation and aren't getting better with standard treatments. The goal is to see if the drug can help shrink or control the cancer.

Study on AGE accumulation in long-term parenteral nutrition patients

This study looks at how certain compounds called AGEs build up in the body of people who rely on long-term parenteral nutrition (nutrition given through a vein). It aims to understand whether this affects health and to find better ways to monitor patients.