Clinical trials · California
Alzheimer’s disease clinical trials in California
We’re tracking 68 recruiting alzheimer’s disease studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05395624RecruitingPhase 1/Phase 2
Safety imaging study of a PET tracer in ALS, Alzheimer, MS, Parkinson
This early-phase study tests the safety of a radioactive tracer (“18F-OP-801”) and how the tracer moves through the body (biodistribution) in people with ALS, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, and in healthy volunteers. It also measures how the body processes the tracer (“pharmacokinetics”) to support future studies.
Stanford, CaliforniaAges 18–80 - NCT07866768Recruiting
Ultrasound treatment to clear brain waste in early memory loss
This study tests a low-intensity ultrasound treatment aimed at helping the brain clear out harmful protein buildup linked to Alzheimer's disease. It is for people 65 and older with mild cognitive impairment (slight but noticeable memory problems) and a positive test for amyloid, a protein in the brain.
San Francisco, CaliforniaAges 65 years+ - NCT07516119Recruiting
Predicting Alzheimer's Risk Before Memory Loss Occurs
This study identifies people at high risk for Alzheimer's disease before symptoms develop, using genetics and digital tools to track brain health over time. If you qualify, you'll help researchers understand who will develop cognitive decline and potentially enable earlier interventions.
San Diego, CaliforniaAges 55 years+ - NCT03638583Recruiting
Online testing study to prevent or spot Alzheimer’s early
This study invites people age 50+ who do not have dementia to do ongoing thinking tests online. If an online risk screen suggests you may be at higher risk, you may be referred for in-person body tests (biomarker assessment).
San Diego, CaliforniaAges 50–85 - NCT07763392Recruiting
Normal cognitive test scores for adults
This study is testing a voice-controlled digital platform to measure normal memory and thinking abilities in healthy adults. By participating, you would help create a baseline of normal scores that doctors can use to compare against when assessing people with thinking problems.
Carlsbad, CaliforniaAges 18–100 - NCT07602582RecruitingPhase 3
Donanemab Extension Study for Alzheimer's Disease
This is a follow-up study for people who already completed a previous donanemab trial (AACM). Donanemab is a medication designed to slow cognitive decline in early Alzheimer's disease by targeting amyloid buildup in the brain.
Riverside, CaliforniaAges 55 years+ - NCT07228078RecruitingPhase 2
Open-label extension for Alzheimer's study completers
This trial continues treatment for people who finished the earlier SNK01-AD01 study. It tests a personalized cell therapy (SNK01) to see if ongoing treatment is safe and helpful for Alzheimer's disease.
Glendale, CaliforniaAges 40–85 - NCT05374278RecruitingPhase 1/Phase 2
PET scan test for a dementia brain tracer
This early-phase study tests a new PET scan tracer that targets a brain chemical transport system involved in dementia. It aims to see if the tracer can safely and clearly show brain changes, which could help future dementia diagnosis or tracking.
San Francisco, CaliforniaAges 40–75 - NCT06410157Recruiting
Mindfulness for heart-brain health in adults 50-70
This study tests whether a daily mindfulness practice can help older adults improve how their heart and brain work together. You will do breathing exercises at home and come to USC twice for check-ups, including blood and urine tests and an MRI.
Los Angeles, CaliforniaAges 50–70 - NCT05929703Recruiting
Caring for hospitalized older adults
This study tests a new approach to caring for older adults in the hospital to prevent confusion (delirium). It involves having a family member or care partner stay with the patient during the hospital stay.
Orange, CaliforniaAges 70 years+ - NCT05704309Enrolling by invitation
Study of diabetes prevention participants using brain scans
This study looks at how people who previously took part in a diabetes prevention program are doing over time, including brain health using MRI scans for some participants. It may help researchers understand who is at higher risk for memory and thinking problems and why.
Alhambra, CaliforniaAges Any age - NCT05641688RecruitingPhase 3
PET brain scan study for people with terminal illness
This Phase 3 study tests an amyloid/tau PET brain imaging agent (called [18F]PI-2620). It aims to see how well the scan helps with brain pathology findings in people who are expected to have a life expectancy of 1 year or less.
Los Angeles, CaliforniaAges 50 years+ - NCT05231785RecruitingPhase 1
Test drug safety for early Alzheimer’s memory trouble
This Phase 1 trial tests how safe and tolerable ALN-APP is in people with early Alzheimer’s-related mild memory impairment or mild dementia. It may help researchers find a treatment path for early Alzheimer’s, while closely monitoring side effects and basic health markers.
La Jolla, CaliforniaAges 18 years+ - NCT04165109Recruiting
Down syndrome study to test memory and thinking changes
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
Orange, CaliforniaAges 25–55 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT07764185RecruitingPhase 2
Recharge and support program for dementia caregivers
This study tests an online program designed to help caregivers of people with Alzheimer's or other dementias recharge and reduce stress. It may help you feel more supported and better able to handle caregiving challenges.
Campbell, CaliforniaAges 18 years+ - NCT07260253Recruiting
Remote brain stimulation for language in primary progressive aphasia
This study tests if a non-invasive brain stimulation technique called tDCS, done at home with remote supervision, can help improve language skills in people with the logopenic variant of primary progressive aphasia (PPA).
San Francisco, CaliforniaAges 40 years+ - NCT06418971Recruiting
Testing a caregiving support platform for dementia caregivers
This study is testing an online platform called CarePair that helps connect family caregivers of people with dementia to resources and support. It may help caregivers find the assistance they need.
Los Angeles, CaliforniaAges 18 years+ - NCT05452031Recruiting
Sleep program for people with dementia and their caregiver
This study tests a “dyadic” sleep health approach, meaning it works with both you and your caregiver together. It aims to improve sleep when dementia is causing frequent sleep problems, and to see whether a caregiver-involved plan helps both of you.
Los Angeles, CaliforniaAges 18 years+ - NCT04240665Enrolling by invitation
Test a digital notebook for memory problems
This study tests a digital “memory notebook” to help people who have early memory concerns keep track and report changes over time. It may be useful if you’re having mild memory issues and can complete surveys with a study partner.
Sacramento, CaliforniaAges 60 years+
Alzheimer’s disease trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting alzheimer’s disease studies listed above.
- University of Southern California · 2 studies
- Alzheimer's Disease Center, University of California, Davis
- Artemis Institute for Clinical Research
- Behavioral Research Specialists, LLC
- Care Access - Huntington Beach
- China Basin, UCSF
- Clinical Trial Site
- Clinical Trials Research
What taking part in a alzheimer’s disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Alzheimer’s disease trials in other states
Common questions
- Are there alzheimer’s disease clinical trials in California?
- Yes. We're currently tracking 68 recruiting alzheimer’s disease studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a alzheimer’s disease study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a alzheimer’s disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New alzheimer’s disease studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.