Clinical trials · Massachusetts
Anxiety clinical trials in Massachusetts
We’re tracking 41 recruiting anxiety studies with a site in Massachusetts — including Phase 2 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT05683223Recruiting
Brain and body markers to improve treatment for social anxiety
This study uses brain recordings (EEG and MRI) to understand how treatments help people with social anxiety. It also looks for signals that may predict who is most likely to benefit from treatment.
Boston, MassachusettsAges 18–50 - NCT04895995Recruiting
Digital CBT program for anxiety after heart or stroke events
This trial tests a scalable online “CBT” program (a structured talking-therapy approach) to reduce generalized anxiety and related health behaviors in people after a recent heart or stroke problem. If you qualify, it may help you learn tools to manage anxiety and health routines in a convenient digital format.
Boston, MassachusettsAges 18 years+ - NCT04557891Recruiting
Low-intensity ultrasound for generalized anxiety disorder
This trial tests a non-drug brain treatment using low-intensity focused ultrasound to reduce symptoms of generalized anxiety disorder (GAD). It may help if your anxiety has been moderate to severe and you’ve already tried standard medications without enough relief.
Boston, MassachusettsAges 18–65 - NCT04912531Recruiting
Virtual reality and smell tools to ease surgery pain
This trial tests whether a combination of virtual reality and guided smells can reduce pain and anxiety around major heart and chest surgeries. If you’re scheduled for one of the listed operations, the study may help make recovery feel more comfortable by using sensory-based distraction.
Boston, MassachusettsAges 18 years+ - NCT05467683Recruiting
Breathing CO2 test to predict which anxiety therapies won’t work
This study uses a controlled breathing test (inhaling CO2 or breathing faster) to see if it can predict whether exposure-based therapy will help your anxiety disorder. If you are in the right group, the results may help doctors choose more effective treatment earlier.
Boston, MassachusettsAges 18–70 - NCT05665491Recruiting
Study links parent anxiety thinking to child anxiety
This study looks at how a parent’s tendency to interpret situations as more threatening or worrying may affect a child’s anxiety. If you and your child fit the requirements, you may complete questionnaires and phone-based check-ins to help researchers understand what patterns matter.
Belmont, MassachusettsAges 7 years+ - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Boston, MassachusettsAges 18–65 - NCT06846320RecruitingPhase 2
Study of ABBV-932 for generalized anxiety disorder
This trial tests an oral medicine called ABBV-932 when added to current antidepressant therapy for people with generalized anxiety disorder (GAD) who still have symptoms. It aims to see if the combination can improve anxiety and reduce side effects.
Springfield, MassachusettsAges 18–65 - NCT07153250Recruiting
Online parent training for young child anxiety
This trial tests an online program that teaches parents how to help their young child (ages 2 to 7) manage anxiety. You would complete the program at home, and researchers want to see if it reduces your child's anxiety symptoms.
Boston, MassachusettsAges 18 years+ - NCT07305740Recruiting
Online program for anxiety in cancer survivors
This study tests an online program to help cancer survivors manage anxiety. You may qualify if you finished cancer treatment at least 4 months ago and still feel significant anxiety.
Boston, MassachusettsAges 18 years+ - NCT07323784RecruitingPhase 2
Study of NTX-1472 for social anxiety disorder
This trial tests an investigational medicine called NTX-1472 to see if it helps people with social anxiety disorder. Participation involves taking the study drug and attending scheduled visits.
Boston, MassachusettsAges 18–65 - NCT05501834Enrolling by invitation
Anxiety study for kids getting arm pins removed
This study tests if a child life specialist can help reduce anxiety when children have pins removed from their arm after a fracture. If your child is between 3 and 10, had a specific arm fracture treated with pins at Boston Children's Hospital, and speaks English, they may be eligible.
Boston, MassachusettsAges 3–10 - NCT05649059RecruitingPhase 4
Cannabidiol study for social anxiety symptoms
This trial studies whether cannabidiol (CBD) helps improve social anxiety symptoms. You may be able to join if you are an adult with significant social anxiety and meet medication and health safety requirements.
Cambridge, MassachusettsAges 18–55 - NCT03723928Recruiting
Blood test–guided monitoring for metastatic breast cancer treatment
This study checks whether specific blood “tumor marker” levels can help monitor how hormone receptor–positive, HER2-negative metastatic breast cancer responds to first-line therapy. It uses regular blood tests (and sometimes scans) to see if this marker-based monitoring is useful and reliable.
Peabody, MassachusettsAges 18 years+ - NCT07217561Recruiting
Doula support program to improve mental health before and after birth
This trial tests whether extra training and resources for doulas can help pregnant people and new parents feel better emotionally. Doulas who join will learn new ways to support clients, and participants will get care from a trained doula.
Boston, MassachusettsAges Any age - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT06723158Recruiting
Virtual reality glasses for oral surgery with sedation
This trial tests if wearing virtual reality (VR) glasses during oral surgery helps patients relax while under IV sedation. It may be a good option if you need sedation for a tooth extraction or other mouth procedure.
Boston, MassachusettsAges 16–65 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05434130RecruitingPhase 2
Testing the right exercise amount to help concussion recovery
This study tests whether adjusting how much exercise you do can improve recovery after a concussion. You may be screened to make sure symptoms are still present, and then assigned to an exercise plan that matches the study’s goals.
Cambridge, MassachusettsAges 13–18 - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05555875Recruiting
Study how people engage with digital mental health tools
This study looks at what helps (or prevents) people from using digital mental health programs. You may join if you have meaningful depression and/or anxiety symptoms and you can use a smartphone for the study apps.
Boston, MassachusettsAges 18–75 - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT05674357Recruiting
Training therapists to help people with cancer distress
This trial trains therapists in evidence-based treatments to reduce distress related to cancer and cancer care. You may be able to join if you’re being treated or followed at MGH Cancer Center and your distress level is high.
Boston, MassachusettsAges 18 years+ - NCT05734313Recruiting
Teletherapy CBT for anxiety and depression in people with diabetes
This trial tests a unified, talk-therapy program delivered by video (telemedicine) to help with anxiety and depressive symptoms. If you have type 1 diabetes and symptoms of anxiety or depression, it may help you learn coping skills and improve mood.
Boston, MassachusettsAges 18–64
Anxiety trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting anxiety studies listed above.
- Massachusetts General Hospital · 5 studies
- Boston University · 4 studies
- McLean Hospital · 3 studies
- Boston Children's Hospital · 2 studies
- Beth Israel Deaconess Medical Center
- Brigham and Women's Hospital
- Center for Anxiety and Related Disorders, Boston University
- Clinical Study Site
What taking part in a anxiety study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Anxiety trials in other states
Common questions
- Are there anxiety clinical trials in Massachusetts?
- Yes. We're currently tracking 41 recruiting anxiety studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a anxiety study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a anxiety trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New anxiety studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.