Clinical trials · Pennsylvania
Arthritis clinical trials in Pennsylvania
We’re tracking 28 recruiting arthritis studies with a site in Pennsylvania — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT06454188RecruitingPhase 4
Upadacitinib for Psoriatic Arthritis with Spine Involvement
This study tests how well upadacitinib (a pill taken daily) works for people with active psoriatic arthritis that also affects the spine. It is for those who have not responded well enough to other treatments like NSAIDs or biologics.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02469662Recruiting
Study of outcomes after Nexel total elbow replacement
This study looks at how well the Nexel total elbow replacement works over time for people who need an elbow replacement due to pain, damage, or instability. It may help the doctors understand which patients benefit most and what results to expect.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07137598RecruitingPhase 2
A study of RO7790121 for moderate to severe rheumatoid arthritis
This study tests a new drug, RO7790121, for people with rheumatoid arthritis (RA) who have not gotten better with or could not tolerate common treatments like TNF inhibitors or JAK inhibitors. It aims to see if the drug is safe and can help reduce joint pain and swelling.
Duncansville, PennsylvaniaAges 18 years+ - NCT07486960RecruitingPhase 2
Study of Tulisokibart for Psoriatic Arthritis
This trial tests a new drug called tulisokibart for people with psoriatic arthritis (PsA), a condition that causes joint pain and skin plaques. It may help if you have not tried certain biologic medications or if they did not work well.
Duncansville, PennsylvaniaAges 18–80 - NCT07412704RecruitingPhase 1/Phase 2
Study of BMS-986528 for hard-to-treat rheumatoid arthritis
This trial tests a new drug called BMS-986528 for people with rheumatoid arthritis that is difficult to treat. It aims to see if the drug can help when other treatments haven't worked well.
Philadelphia, PennsylvaniaAges 18–65 - NCT07409103RecruitingPhase 2
Testing ELV001 for active rheumatoid arthritis
This study tests a new medication, ELV001, for people with active rheumatoid arthritis who haven't improved enough with methotrexate and a TNF inhibitor. The goal is to see if different doses of ELV001 are safe and can help reduce joint pain and swelling.
Duncansville, PennsylvaniaAges 18–75 - NCT07321873RecruitingPhase 2
Study of JNJ-88545223 for Active Psoriatic Arthritis
This study tests an experimental drug called JNJ-88545223 to see if it can reduce joint pain, swelling, and skin plaques in people with active psoriatic arthritis. It may help if you have both joint symptoms and psoriasis.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07223138Enrolling by invitationPhase 3
Long-term safety study of sonelokimab for psoriatic arthritis
This study is for people who have already been in a previous trial of sonelokimab for psoriatic arthritis and want to continue treatment. It checks how safe and effective the medicine is over a longer time.
Duncansville, PennsylvaniaAges 18 years+ - NCT06972446RecruitingPhase 2
Targeted therapies for rheumatoid arthritis
This study tests different targeted treatments for adults with rheumatoid arthritis who have already tried other biologic or targeted medications and need a new option. It aims to find which treatment works best for people like you.
Duncansville, PennsylvaniaAges 18 years+ - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT06865105RecruitingPhase 2
Targeted treatments for active psoriatic arthritis
This study tests targeted medications for people with active psoriatic arthritis (PsA) who have already tried 1 or 2 other advanced treatments without success or couldn't tolerate them. The goal is to see if these newer options can better control joint pain and skin symptoms.
Duncansville, PennsylvaniaAges 18 years+ - NCT06807424RecruitingPhase 3
Study of icotrokinra for active psoriatic arthritis
This trial tests a new medication called icotrokinra for people with active psoriatic arthritis (PsA). It aims to see how well the drug works and if it is safe, including for those who have tried other treatments.
Duncansville, PennsylvaniaAges 18 years+ - NCT06751238RecruitingPhase 1
Secukinumab for children with psoriatic arthritis
This study tests a drug called secukinumab (given through an IV) in children with juvenile psoriatic arthritis. The goal is to see how well it works and if it's safe over time, for up to 6 years.
Pittsburgh, PennsylvaniaAges 2–17 - NCT06671483RecruitingPhase 3
Zasocitinib for psoriatic arthritis without prior biologic use
This trial tests an oral medication called zasocitinib for adults with psoriatic arthritis who have not tried biologic medicines before. It aims to see if the drug can improve joint pain, swelling, and skin symptoms.
Wyomissing, PennsylvaniaAges 18 years+ - NCT06671054RecruitingPhase 2
Testing AP1189 for newly diagnosed active rheumatoid arthritis
This study tests an oral drug called AP1189 for people just diagnosed with active rheumatoid arthritis who haven't yet taken standard arthritis medicines. You may be able to take part if your disease is very active and you're ready to try a new treatment option.
Duncansville, PennsylvaniaAges 18 years+ - NCT05961592RecruitingPhase 1
Study drug R-2487 for people with active rheumatoid arthritis
This Phase 1 study tests how the drug R-2487 behaves in the body and looks at early safety in adults with active rheumatoid arthritis. If you have ongoing joint inflammation despite standard treatments, this trial may offer a chance to try an investigational therapy under close monitoring.
Duncansville, PennsylvaniaAges 18–75 - NCT05658575RecruitingPhase 2/Phase 3
Tablets to treat sudden gout flare pain
This trial studies dapansutrile tablets (OLT1177) to see how well they work for people in the first 4 days of an acute gout flare. It may help reduce pain and inflammation in the specific joint where your gout is flaring.
Duncansville, PennsylvaniaAges 18 years+ - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune disease
This trial tests whether the immunotherapy drug nivolumab can safely treat advanced cancer in people who also have an autoimmune disease like rheumatoid arthritis, lupus, or multiple sclerosis. It aims to find out if the drug may help control cancer while managing their autoimmune condition.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06319911Recruiting
Testing a new shoulder replacement implant system
This study tests a new shoulder implant system for people who need their first shoulder replacement due to arthritis or a shoulder deformity. It helps researchers see how well the implant works and if it improves shoulder function and pain.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05003310Recruiting
Splenic stimulation study for active rheumatoid arthritis
This study tests a treatment that stimulates the spleen to help calm symptoms of active rheumatoid arthritis (RA). It’s mainly for people whose RA has not improved enough after several newer arthritis medicines.
Altoona, PennsylvaniaAges 22–75 - NCT07704580RecruitingPhase 1/Phase 2
Sarilumab for active rheumatoid arthritis
This trial tests sarilumab, an injected antibody that blocks a key protein involved in inflammation, for people with moderate-to-severe rheumatoid arthritis (RA) who haven't had success with standard treatments. The goal is to see if adding sarilumab can help control joint pain and swelling.
Duncansville, PennsylvaniaAges 18 years+ - NCT07290036RecruitingPhase 1
Testing different ways to give bimekizumab for psoriatic arthritis or axial spondyloarthritis
This study looks at whether giving bimekizumab in different ways is safe and how it moves through the body over time. It is for adults with active psoriatic arthritis or axial spondyloarthritis who may benefit from bimekizumab treatment.
Duncansville, PennsylvaniaAges 18 years+ - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Philadelphia, PennsylvaniaAges 40–90
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting arthritis studies listed above.
- Altoona Center for Clinical Research · 6 studies
- Clinical Research Philadelphia · 2 studies
- Rothman Orthopaedic Institute · 2 studies
- UPMC Children's Hospital of Pittsburgh · 2 studies
- Altoona Arthritis & Osteoporosis Center
- Altoona Center for Clinical Research ( Site 5110)
- Altoona Center For Clinical Research /ID# 272593
- Altoona Center for Research
What taking part in a arthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Arthritis trials in other states
Common questions
- Are there arthritis clinical trials in Pennsylvania?
- Yes. We're currently tracking 28 recruiting arthritis studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a arthritis study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a arthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New arthritis studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.