Clinical trials · Boston, MA
Bipolar Disorder clinical trials in Boston
We’re tracking 18 recruiting bipolar disorder studies with a site in or near Boston — including Phase 1/Phase 2, Phase 2 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT06107764Recruiting
Brain stimulation study for thinking and memory in psychosis
This trial tests whether a non-invasive brain stimulation technique (rTMS) can improve thinking and memory in people with psychosis. It involves MRI scans and several study visits at McLean Hospital.
Boston, MassachusettsAges 18–55 - NCT07211217Recruiting
Time-restricted eating for bipolar depression
This study tests if eating only during a specific daily window can help with weight loss and mood in people with bipolar disorder who are currently depressed and overweight.
Boston, MassachusettsAges 18–65 - NCT04580134RecruitingPhase 4
Clozapine study for people with a specific schizophrenia or bipolar type
This trial tests whether clozapine works better for people whose illness fits a specific “biotype-1” pattern. It may help reduce ongoing symptoms, but it also requires close safety monitoring.
Boston, MassachusettsAges 18–60 - NCT06071858Recruiting
Enhanced coordinated care for early psychosis
This trial studies an enhanced version of coordinated specialty care (CSC) for people experiencing their first episode of psychosis. It aims to improve outcomes by providing more intensive support and coordination among different healthcare providers.
Boston, MassachusettsAges Any age - NCT07540338RecruitingPhase 1/Phase 2
New Lithium Capsule Study for Bipolar I
This study compares a new lithium capsule (AL001) to a standard lithium capsule in people with Bipolar I Disorder. It aims to see how well your body absorbs each capsule and whether AL001 is safer or more tolerable.
Boston, MassachusettsAges 18–65 - NCT06740383Recruiting
Study of early psychosis and treatments
This study looks at people who have had psychosis for less than 4 years to understand how their symptoms change over time and how they respond to treatment. By using brain scans and other tests, researchers hope to find better ways to personalize care for early psychosis.
Boston, MassachusettsAges 18–40 - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT06373016Recruiting
Ketone drink study for stable bipolar disorder
This study tests whether a ketone drink can change how the body uses energy in people with bipolar disorder. It may help understand new ways to manage the condition.
Charlestown, MassachusettsAges 18–45 - NCT06274567Recruiting
Brain stimulation for emotion in bipolar depression
This study tests a safe, non-invasive brain stimulation technique called iTBS to see if it can help people with bipolar disorder better manage their emotions during a depressive episode. It may offer a new option for those who are still feeling depressed despite stable medication.
Charlestown, MassachusettsAges 24–65 - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT07286175RecruitingPhase 2
Study of brenipatide for bipolar disorder
This trial tests an experimental drug called brenipatide for people with bipolar I or II disorder. It aims to see if the drug can help manage mood episodes when added to your current stable medications.
Watertown, MassachusettsAges 18–75 - NCT06221852Recruiting
Ketogenic diet for first episode bipolar disorder
This study tests whether a special high-fat, low-carbohydrate diet (ketogenic diet) can help people who have recently been diagnosed with bipolar disorder. It may improve mood stability and overall brain health.
Belmont, MassachusettsAges 18–45 - NCT06558201Enrolling by invitation
Open-label extension for completers of earlier study
This trial is for people who finished a 12-week study (NCT06221852) and still meet its original requirements. It offers continued access to the study treatment.
Belmont, MassachusettsAges 18–45 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+ - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+
Hear when a new Bipolar Disorder trial opens near Boston, MA
We’ll email you when one opens near Boston, MA — at most once a week, no account needed, unsubscribe anytime.
Bipolar Disorder trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting bipolar disorder studies listed above.
- McLean Hospital · 8 studies
- Massachusetts General Hospital · 4 studies
- Beth Israel Deaconess Medical Center · 3 studies
- Athinoula A. Martinos Center for Biomedical Imaging · 2 studies
- Butler Hospital · 2 studies
- Adams Clinical
- Boston Medical Center
- Cambridge Health Alliance
What taking part in a bipolar disorder study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting bipolar disorder studies in Massachusetts.
Common questions
- Are there bipolar disorder clinical trials near Boston?
- Yes. We're currently tracking 18 recruiting bipolar disorder studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a bipolar disorder study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a bipolar disorder trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New bipolar disorder studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.