Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,170 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06891651Recruiting
21-gene testing for older breast cancer patients with lymph node spread
This trial looks at using a 21-gene test to guide treatment decisions for women aged 65 or older who have breast cancer that has spread to lymph nodes. It aims to see if this test can help avoid unnecessary chemotherapy in this group.
Jinan, ShandongAges 65 years+ - NCT06890221Recruiting
Nutrition therapy before and after breast cancer surgery
This trial tests if a special nutrition drink before and after mastectomy can help breast cancer patients recover better. It uses a body measurement called bioimpedance phase angle to see how nutrition affects your cells and healing.
Petaling Jaya, Kuala LumpurAges 18 years+ - NCT07263451Recruiting
Testing a new treatment for small, early breast cancers
This study tests if a new treatment called IRE (irreversible electroporation) can safely treat small, early-stage breast cancers. It's for people with a single, small tumor that has not been treated yet.
Hangzhou, ZhejiangAges 18 years+ - NCT07262138Recruiting
Active monitoring for older women with early breast cancer
This trial studies whether active monitoring (watchful waiting) can be a safe option instead of immediate surgery or other treatments for women 70 and older who have a small, slow-growing type of breast cancer. If you join, you will not have surgery or other treatments right away, but your cancer will be closely watched.
Pittsburgh, PennsylvaniaAges 70 years+ - NCT07251868Recruiting
Study of SG in breast cancer with brain metastases
This study follows patients with breast cancer that has spread to the brain and who have already received the drug Sacituzumab Govitecan (SG). The goal is to learn how well SG works in real-world settings and to see how patients are doing over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07258563Recruiting
Can a special diet prevent taste changes from chemo?
This study looks at whether a special diet can help prevent taste changes during chemotherapy. It is for people with certain cancers who are about to start treatment.
AmsterdamAges 18–70 - NCT06900647RecruitingPhase 1
Bortezomib plus cisplatin for advanced breast cancer
This study tests a combination of two drugs, bortezomib and cisplatin, for people with breast cancer that has spread or come back after standard treatments. The goal is to see if this combination can help shrink or control the cancer.
Guangzhou, GuangdongAges 18 years+ - NCT07227233RecruitingPhase 2
AI-guided retrial of CDK4/6 inhibitors for advanced breast cancer
This trial tests whether an artificial intelligence (AI) tool can help doctors decide if it is safe and effective to give you a second course of a CDK4/6 inhibitor drug (like palbociclib, ribociclib, or abemaciclib) plus hormone therapy for advanced (unresectable or metastatic) HR+/HER2- breast cancer. The goal is to only treat people whose cancer is likely to respond based on a special AI analysis of their tumor tissue.
La Jolla, CaliforniaAges 18 years+ - NCT07225309Recruiting
Meaning-Centered Therapy for Mexican Adults with Advanced Cancer
This study tests a therapy program called Meaning-Centered Therapy designed to help adults in Mexico with advanced cancer find meaning and improve their well-being. It involves sessions delivered by trained providers at the National Cancer Institute in Mexico (INCan).
New York, New YorkAges 18 years+ - NCT07227038Recruiting
Living well with advanced breast cancer study
This study looks at a program called Living Well With Advanced Breast Cancer, which offers support to people with metastatic breast cancer and their caregivers. It aims to see how helpful the program is for different groups of people, including those who haven't tried it yet, those who cancelled, and those who finished it.
Columbus, OhioAges 18 years+ - NCT06911528Recruiting
New cell-probing technology for early breast cancer surgery
This trial tests a new technology that helps doctors examine cells during surgery for early-stage breast cancer. It may help make the sentinel lymph node biopsy more accurate.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06006806Recruiting
Proton therapy skin effects study for breast cancer
This study looks at how proton therapy affects the skin in people being treated for early-stage breast cancer. It aims to understand skin reactions better so doctors can reduce side effects.
Knoxville, TennesseeAges 18 years+ - NCT07215364Recruiting
Exercise and quality of life in early breast cancer on hormone therapy
This trial tests if a supervised exercise program can improve quality of life for people with early-stage breast cancer who are currently taking hormone therapy (aromatase inhibitors with or without CDK4/6 inhibitors). It aims to see if exercise helps reduce side effects like fatigue and pain.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT07218432Recruiting
TheraBionic device study for hormone-positive breast cancer
This trial tests a device called TheraBionic P1, which uses low-level radiofrequency energy, for women with early-stage hormone receptor-positive, HER2-negative breast cancer. It is given before surgery to see if it can help shrink the tumor.
Clarkston, MichiganAges 22 years+ - NCT07211178Recruiting
Tracking cancer DNA in blood to detect early return of breast cancer
This study tracks tiny traces of cancer DNA in the blood over time to see if it can find early signs of breast cancer coming back. It looks at different types of breast cancer and at different points in a patient's treatment journey.
Birmingham, AlabamaAges 18–99 - NCT06926543RecruitingPhase 3
Timing of radiation with chemotherapy for breast cancer
This trial compares two ways of giving radiation therapy to people with stage IIB or III breast cancer: either at the same time as chemotherapy or after chemotherapy finishes. It aims to find which approach works better while keeping side effects manageable.
Vishkhapatnam, Andhra PradeshAges 18 years+ - NCT07208084Recruiting
A support program for Black women with breast cancer
This study tests a program called Project SOAR that offers group support and education for Black American women with breast cancer. It aims to help them feel more empowered and connected during their journey.
Los Angeles, CaliforniaAges 18 years+ - NCT07206394Recruiting
Scar massage for pain after breast cancer surgery
This trial tests if a gentle scar massage technique called ScarWork can help reduce pain that continues after breast cancer surgery and radiation. If you are at least 6 months past radiation and still have pain, this study may be a good fit for you.
LondonAges 18 years+ - NCT06931548Recruiting
Preserving the breast fold in reconstruction
This study tests a surgical technique to better preserve the natural fold under the breast (the inframammary fold) during implant-based breast reconstruction. It may help improve the cosmetic result after breast cancer treatment.
Moscow, Skolkovo Innovation CenterAges 18 years+ - NCT05288777RecruitingPhase 2/Phase 3
Testing follow-up chemo and radiation for high-risk breast cancer
This trial studies a standard follow-up treatment plan that combines chemotherapy and radiation after surgery, and it looks for blood/tissue “biomarkers” that predict who benefits most. If you have high-risk breast cancer that didn’t fully disappear after initial (neoadjuvant) chemo, you may be eligible to help guide better future treatment choices.
Charlottesville, VirginiaAges 18 years+ - NCT06777420Recruiting
Question list for breast cancer patients before chemo
This study tests whether a list of helpful questions can improve communication and care for breast cancer patients who will receive chemotherapy before surgery. It aims to support patients in talking with their doctors about what matters most to them.
Uppsala, Region UppsalaAges 18 years+ - NCT06938360Recruiting
Breast-conserving surgery for central breast cancer study
This trial compares breast-conserving surgery (removing only the tumor and nearby tissue) to total mastectomy (removing the whole breast) for women with breast cancer in the central area of the breast. The goal is to see if the less extensive surgery works just as well.
Xi'an, ShaanxiAges 18–70 - NCT06476119Recruiting
Optimizing treatment for low stage triple-negative breast cancer with high immune cells
This trial tests whether people with early stage triple-negative breast cancer and a high level of immune cells in the tumor can safely skip chemotherapy after surgery. It aims to find a less intensive treatment option for those who may not need strong drugs.
Sittard-Geleen, LimburgAges 18 years+ - NCT07191717RecruitingPhase 2
Imlunestrant and abemaciclib for early ER+ breast cancer
This trial tests whether adding two targeted drugs, imlunestrant and abemaciclib, to your usual hormone therapy can lower the chance of your breast cancer coming back. It is for people with early-stage ER+ breast cancer who have no signs of cancer on scans but have tiny amounts of tumor DNA in their blood (called ctDNA).
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,170 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.