Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 575 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05460468Recruiting
Brain stimulation study to improve memory in aging
This study tests a brain-stimulation approach to help improve memory as people age. You may be able to take part if you can consent and meet safety and medical criteria, especially related to brain/nerve health and seizure risk.
Durham, North CarolinaAges 18–75 - NCT07659964Recruiting
Rhythmic music and walking study for Alzheimer's
This study tests whether listening to a steady beat (rhythmic music) while walking can improve movement and brain function in people with mild Alzheimer's disease. Healthy volunteers are also needed for comparison.
Boston, MassachusettsAges 50–90 - NCT07583251RecruitingPhase 1
Safety of a supplement for mild memory loss
This trial tests an oral supplement called gamma glutamylcysteine (GGC) in people with mild cognitive impairment (MCI) to see if it is safe and well-tolerated. It may help by supporting the body's natural defenses against cell damage.
Pittsburgh, PennsylvaniaAges 55–80 - NCT06050603Recruiting
MRI guided brain stimulation study for memory
This study tests a new way to use brain stimulation guided by MRI to understand memory. It may help people with mild memory problems or healthy volunteers.
Toronto, OntarioAges 18–80 - NCT04956549Recruiting
Exercise program for early memory loss in African Americans
This study tests whether a structured exercise program can lower Alzheimer’s risk in older African American adults who have mild cognitive impairment (MCI). You’ll be placed by chance into an exercise group or a comparison group and attend group sessions for about a year.
Baton Rouge, LouisianaAges 60 years+ - NCT06315231RecruitingPhase 2
Stroke Recovery Thinking Trial for Recent Stroke Patients
This study tests an under-the-tongue tablet (edaravone dexborneol) to help thinking and memory problems that can happen after an ischemic stroke. It may help people who recently had a stroke and now have trouble with attention, memory, or planning.
Fuyang, AnhuiAges 40–80 - NCT07454473RecruitingPhase 4
Edaravone and Dexborneol for chemo-related memory loss
This trial tests if a sublingual tablet can help people who have memory and thinking problems related to chemotherapy. If you have had certain types of chemotherapy and now notice trouble with your memory or concentration, this treatment might help improve your symptoms.
Shenyang, LiaoningAges 35–80 - NCT07591857Recruiting
Computer-Based Brain Training for Cancer-Related Memory Loss
This study tests whether a computer-based brain training program delivered in a group setting can help women who experienced memory or thinking problems after breast cancer treatment. The program is designed to retrain and improve how your brain processes information.
JerusalemAges 18 years+ - NCT05697588Recruiting
Study blood and brain markers from mild memory loss to dementia
This study looks for “biomarkers” (measurable signs from blood and brain tests) that may help predict who with mild cognitive impairment (MCI) could later develop dementia. Results may help doctors spot risk earlier and better plan care.
Beijing, Beijing MunicipalityAges 50–85 - NCT07042633Recruiting
Gamma brain waves and memory in small vessel disease study
This study looks at how brain waves in certain areas may affect memory in people with cerebral small vessel disease. It uses EEG, a safe way to measure brain activity, along with imaging and thinking tests, to understand why some people have memory trouble.
Beijing, Beijing MunicipalityAges 55–75 - NCT07029386Recruiting
Brain stimulation for thinking problems in MS and NMOSD
This trial tests a gentle brain stimulation technique (transcranial electrical stimulation) to see if it can improve thinking and memory problems in people with inflammatory brain diseases like MS or NMOSD. It may help if you feel your thinking has slowed down.
BeijingAges 18–65 - NCT06634147Recruiting
Exercise program to prevent decline in hospitalized older adults
This study is testing a gentle exercise program for older adults (75+) while they are in the hospital. The goal is to see if it helps prevent loss of strength, memory, or thinking skills.
Pamplona, NavarreAges 75 years+ - NCT07724132RecruitingPhase 3
Treatments for sustained response in Alzheimer's disease
This study tests whether a treatment (atomoxetine or metformin) can help people with Alzheimer's disease maintain an improved state for at least 18 months. It may help you or a loved one stabilize symptoms and slow disease progression.
CambridgeAges 55 years+ - NCT04239079Recruiting
Study of immune-related changes in Parkinson’s and Alzheimer’s
This study looks for “autoimmune-like” (immune-system) features in brain-related diseases such as Parkinson’s and Alzheimer’s, using genetic testing and other assessments. Results may help researchers understand what drives these conditions and who might be more likely to have immune-related changes.
New York, New YorkAges 55–90 - NCT05514106Enrolling by invitationPhase 4
MIBG heart scan study for aging and neurologic conditions
This Phase 4 study tests how an iodine-based heart scan (a special imaging test) works in people with certain neurologic diagnoses and aging-related conditions. It may help researchers better understand the heart-brain connection in these disorders and improve future care.
Rochester, MinnesotaAges 40–90 - NCT07441122Recruiting
Brain game for focus: Using brain-computer tech in older adults
This study tests if a brain-computer interface can help older adults improve attention. You'll use a computer that reads your brain signals and gives feedback to train your focus.
Austin, TexasAges 18–90 - NCT06102486Recruiting
Speech in noise study for mild cognitive impairment
This study looks at how well people with mild cognitive impairment (MCI) understand speech in noisy settings. It aims to find better ways to diagnose and help people with thinking and memory concerns.
Lebanon, New HampshireAges 55–80 - NCT07125378RecruitingPhase 1/Phase 2
Exercise program for older adults with memory decline
This six-week exercise program helps older adults with mild memory or thinking problems and trouble walking stay independent and safe at home. You will work with a trainer and wear an activity tracker to track your progress.
Gainesville, FloridaAges 65–90 - NCT07234357Recruiting
Scent therapy for mood and behavior in early dementia
This trial uses pleasant scents (aromatherapy) to see if they can improve mood and behavior for people with early memory loss. It is designed for individuals who have a caregiver who can help them participate.
SingaporeAges 50–99 - NCT03140865Recruiting
Alzheimer’s disease research core for brain and memory testing
This study group collects detailed information from people with normal memory, mild cognitive impairment, or mild Alzheimer’s disease to support Alzheimer’s research. You may need multiple visits, brain scans, and sometimes a spinal fluid sample, with strict health and medication requirements to keep results clear.
Winston-Salem, North CarolinaAges 55 years+ - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT03574207Recruiting
Brain stimulation study for memory in certain adults
This study tests a targeted, non-surgical brain stimulation method to help people with memory, especially remembering facts over time. It compares healthy adults and adults with amnestic mild cognitive impairment (aMCI), using sessions plus brain scans and memory testing.
Omaha, NebraskaAges 19 years+ - NCT03702907Recruiting
Study of aging and a brain sample bank
This study follows adults as they age and may collect biological samples for future research. It could help researchers understand early and late changes related to aging and brain health.
Washington D.C., District of ColumbiaAges 45 years+ - NCT03761381Recruiting
Eye scan study for mild Alzheimer’s and memory changes
This study uses detailed eye imaging (an eye scan) to look for signs related to probable Alzheimer’s disease and mild dementia. It may help researchers understand whether eye scans can reflect brain changes and improve detection.
Portland, OregonAges 55 years+
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Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 575 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.