Clinical trials
Colon Cancer Screening clinical trials
Below are recruiting colon cancer screening clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07127874RecruitingPhase 1
Study of PHN-012 for advanced solid tumors
This trial tests a new drug called PHN-012 for people with advanced colorectal, non-small cell lung, or pancreatic cancer who have already tried at least one standard treatment. The goal is to see if the drug can help shrink or slow tumor growth.
Los Angeles, CaliforniaAges 18 years+ - NCT04120701RecruitingPhase 3
Using blood DNA tests to guide colon cancer treatment after surgery
This trial tests whether a blood test that looks at cancer DNA can help decide whether you need “adjuvant” (extra) chemotherapy after colon cancer surgery. It may help some patients avoid unnecessary chemotherapy while still keeping the cancer from coming back.
DijonAges 18–75 - NCT04920149RecruitingPhase 2
Mesalamine to help prevent colon cancer in Lynch syndrome
This trial tests whether mesalamine, a medicine used for bowel inflammation, can help prevent colorectal cancer in people with Lynch syndrome who do not currently have cancer. It may help by lowering the chance that new pre-cancer growths form over time.
AalborgAges 30 years+ - NCT07279077RecruitingPhase 2
Low-dose radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07046468Recruiting
Smart pill to check gut health in colon inflammation and cancer
This trial tests a smart pill that measures gut health in people with colon inflammation (ulcerative colitis) or colon cancer. It aims to see if the pill can help doctors better understand how the gut is working during treatment or before surgery.
Nijmegen, GelderlandAges 18 years+ - NCT05775146RecruitingPhase 2
Radiation to liver metastases after colon cancer treatment
This trial studies giving targeted high-dose radiation (SBRT) to liver metastases from colorectal cancer after initial treatment, with the goal of improving long-term control or cure. It may help people who have a limited number of liver spots that doctors think can be treated safely and effectively.
Edmonton, AlbertaAges 18 years+ - NCT07669454RecruitingPhase 3
Nuvastatic® for metastatic colorectal cancer
This trial tests a new capsule (Nuvastatic®) added to standard chemotherapy for people with metastatic colorectal cancer. The goal is to see if it helps shrink tumors and improve well-being.
Visakhapatnam, Andhra PradeshAges 18–65 - NCT06567782RecruitingPhase 2
Immunotherapy plus chemotherapy vs. chemotherapy alone for stage 3 colon cancer
This trial tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (CAPEOX) is more effective than chemotherapy alone for people with a specific type of colon cancer (MMRp/MSS) that has not spread. It is given before surgery to shrink the tumor.
AalstAges 18 years+ - NCT06111105Recruiting
Comparing blood tests to guide colon cancer treatment
This study compares different blood tests to find the best way to detect tiny bits of cancer DNA after surgery for stage III colorectal cancer. It aims to help doctors decide if additional chemotherapy is needed to prevent the cancer from coming back.
Graz, StyriaAges 18 years+ - NCT07696793RecruitingPhase 4
Simethicone colonoscopy prep for cancer screening
This trial tests a colonoscopy preparation drink that contains simethicone (a gas-relief ingredient) to see if it works better than standard prep for people who are already scheduled for a screening colonoscopy after a positive stool test. It may help make the procedure more comfortable and effective.
Barcelona, BarcelonaAges 50–69 - NCT02595957Recruiting
Study about how people understand genetic test results
This trial studies what people and families think and understand about genetic test results, especially when results suggest a higher risk for disease. It may also include interviews and follow-up, and in some cases additional family testing if it fits the study’s goals.
Bethesda, MarylandAges 1 month–105 years - NCT04967183Recruiting
Compare a stool blood test versus colonoscopy follow-up after precancer removal
This study compares two ways of checking for colorectal cancer risk after advanced polyps are removed. It may help determine whether a stool test can safely replace some colonoscopy surveillance for certain people.
OurenseAges 50–65 - NCT06081647Recruiting
Testing a new airway device for endoscopy
This trial tests a special mouth-and-throat device designed to help you breathe easier during a routine endoscopy or colonoscopy. If you are a generally healthy adult scheduled for one of these procedures, you may be able to join.
Nanjing, JiangsuAges 18–60 - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70 - NCT06287814Recruiting
Blood test to detect leftover cancer DNA in colorectal cancer patients
This study uses a simple blood test (liquid biopsy) to look for tiny bits of tumor DNA remaining after colorectal cancer surgery. It aims to see if the test can help predict whether the cancer will come back, especially in people with stage III cancer who will receive chemotherapy.
Montpellier, HéraultAges 18 years+ - NCT05686499Recruiting
Colonoscopy training for early colorectal cancer detection
This trial supports training for healthcare professionals to improve screening and early diagnosis of colorectal cancer. It may help by building skills in safely performing colonoscopies and spotting cancer earlier.
Ile-Ife, Osun StateAges 18 years+ - NCT07433673RecruitingPhase 2
Gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab for locally advanced bile duct cancer
This trial tests a combination of four drugs to see if they shrink locally advanced bile duct or gallbladder cancer that cannot be removed surgically. It is for people who have not had prior treatment for this cancer.
New York, New YorkAges 18 years+ - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT06887244Recruiting
Nurse phone support before colonoscopy
This trial studies whether a nurse phone call before an elective colonoscopy can improve the procedure experience, reduce anxiety, and lower financial stress.
NaplesAges 18–80 - NCT05935124Recruiting
White light or narrow-band imaging for colon polyp detection
This trial compares two camera light styles during screening colonoscopy to see which one better finds polyps on the right side of the colon. If you’re having a routine screening and have no concerning symptoms, the results may help improve how doctors spot polyps early.
Sydney, New South WalesAges 18 years+ - NCT05051046Recruiting
Screening colonoscopy with hypnosis for colorectal cancer
This trial studies whether using hypnosis during a screening colonoscopy can help people better tolerate the procedure and complete it comfortably. It’s for adults who are scheduled for a routine screening colonoscopy and meet specific safety and communication requirements.
AngersAges 18–100 - NCT00843375Recruiting
Testing stool samples to find early colon cancer and polyps
This study checks stool samples to see how well stool tests can detect early colon cancer and precancerous growths called adenomas. If you qualify, you’ll collect stool samples for a lab test (FIT) and sometimes this helps sort who should get follow-up testing.
Los Angeles, CaliforniaAges 18 years+ - NCT06931860Enrolling by invitation
Mailed colon cancer screening test comparison
This trial compares two home colon cancer screening tests, Cologuard and FIT, mailed directly to you. It aims to see which one helps more people complete screening and find the test that works best for you.
La Jolla, CaliforniaAges 45–49
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Common questions
- Are there clinical trials for colon cancer screening?
- Yes. Clin2 currently lists 95 recruiting colon cancer screening studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colon cancer screening trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colon cancer screening trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.