Clinical trials
Colorectal Cancer (CRC) clinical trials
Below are recruiting colorectal cancer (crc) clinical trials, each written for real people, not researchers. We’re tracking 320 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03539822RecruitingPhase 1/Phase 2
Cabozantinib and immunotherapy for advanced stomach or bowel cancers
This early-phase study tests a combination of anti-cancer pills and immune-based treatment for people with advanced stomach, esophagus, colorectal, or liver cancer. It aims to shrink tumors and see how safe the treatment is, including whether biopsy testing can help guide future care.
Westwood, KansasAges 18 years+ - NCT05785780Enrolling by invitation
Help improve colon cancer screening for people with diabetes
This study looks for better ways to make sure people with diabetes get up-to-date colon cancer screening. If you haven’t had the recommended test on time, it may help identify barriers in primary care and improve screening follow-through.
New Brunswick, New JerseyAges 50–74 - NCT06265285RecruitingPhase 2
Nivolumab at home vs. clinic for cancer treatment
This study compares giving the immunotherapy drug nivolumab as a shot under the skin at home versus in the clinic. It is for people with certain cancers who are already taking or starting nivolumab.
Jacksonville, FloridaAges 18 years+ - NCT07277322RecruitingPhase 1/Phase 2
Two immunotherapy drugs before surgery for MSS colorectal cancer with liver spots
This trial tests a combination of two immunotherapy drugs (Dupilumab and Toripalimab) before surgery for people with MSS colorectal cancer that has spread to the liver. The goal is to see if this treatment can shrink the liver tumors and help the body's immune system fight the cancer.
New York, New YorkAges 18 years+ - NCT06757192Recruiting
Colorectal cancer screening study for adults 45-54
This study is looking for people aged 45 to 54 who have not been screened for colorectal cancer (CRC) yet. It aims to understand and improve screening rates. You may be eligible if you are a patient at the health center and have no personal or family history of colorectal cancer.
Boston, MassachusettsAges 45–54 - NCT06542835Recruiting
Telehealth support for colorectal cancer screening
This study tests whether telehealth support can help people get recommended colorectal cancer screening. It may be a good fit if you haven't been screened recently and are willing to use your phone for health guidance.
Los Angeles, CaliforniaAges 45–64 - NCT05844514Recruiting
Breath test study for colorectal cancer detection and risk
This study tests a breath analysis (a sample you give by breathing into a device) to help detect or better understand colorectal cancer. It may help researchers see whether breath results can identify cancer sooner and in people who haven’t started treatment yet.
LondonAges 18 years+ - NCT06117241Recruiting
Reducing metabolic risk in couples after colon polyp diagnosis
This study tests a program to improve metabolic health in couples where one person had colon polyps. You and your partner may join if you both are overweight or obese, live together, and share meals.
Columbia, South CarolinaAges 9–55 - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT04510129Recruiting
Cancer biospecimen collection study for immunotherapy patients
This study collects samples (like tissue biopsies and imaging information) from people with certain cancers who are starting anti–PD-1/PD-L1 immunotherapy. It helps researchers gather material to study how these treatments work.
San Francisco, CaliforniaAges 18 years+ - NCT07417488RecruitingPhase 1
Vaccine therapy for advanced colorectal and small bowel cancer
This trial tests a vaccine therapy for people with advanced colorectal or small bowel cancer that has spread or can't be removed. The vaccine targets a protein found on cancer cells to help your immune system fight the cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05501353Recruiting
Study tumor biomarkers in recurrent metastatic colon cancer
This study looks for blood/tumor signals (“biomarkers”) that may help predict outcomes in people whose colorectal cancer returns and spreads after surgery. It mainly helps researchers understand who may do better or worse, which can guide future care.
Hangzhou, ZhejiangAges 18–99 - NCT07345676Recruiting
Helping patients complete colorectal cancer screening
This trial is testing a simple program to help people who are due for colorectal cancer screening to complete their test. It's for patients at Cornell Scott Hill Health who either haven't finished a screening order or had an abnormal stool test without follow-up.
New Haven, ConnecticutAges 45–75 - NCT05784688RecruitingPhase 1/Phase 2
TU2218 with Keytruda for advanced solid tumors
This trial studies TU2218 taken with Keytruda (pembrolizumab) in adults with advanced solid cancers that have limited treatment options. The goal is to see if the combination can shrink tumors and is safe enough to keep using.
San Antonio, TexasAges 18 years+ - NCT05655780Recruiting
Irinotecan care guided by tumor genes and gut bacteria
This study looks at whether a patient’s tumor genetic makeup and gut bacteria activity can predict how well irinotecan-based treatment works and what side effects they might have. It may help personalize treatment to improve survival and quality of life for people with metastatic or unresectable colon cancer.
Maastricht, LimburgAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT03748485Recruiting
Chemo after surgery for certain stage III colon cancer
This trial studies whether adding chemotherapy after surgery helps people with colon cancer that was diagnosed before surgery as stage III and later found to be without certain high-risk features. It may help lower the chance the cancer comes back, but you must meet specific surgery and health criteria.
Guangzhou, GuangdongAges 18–75 - NCT06972160Recruiting
Boosting colorectal cancer screening in Barcelos/Esposende
This study looks at ways to help more people get screened for colorectal cancer. If you're between 50 and 74 and haven't had certain screenings recently, you may be able to join.
PortoAges 49–75 - NCT05410977Recruiting
Testing blood and stool for colon cancer in Lynch syndrome
This study collects blood and stool samples to see how well they can detect colorectal cancer or advanced growths in people with Lynch syndrome (an inherited colon cancer risk) or suspected Lynch syndrome. It may help find cancer or precancer earlier, which can improve next-step decisions.
Scottsdale, ArizonaAges 18 years+ - NCT03837782Enrolling by invitation
Surgery outcomes for early to mid-stage colon cancer
This study looks at how well surgery works for people with colorectal cancer that has not spread to distant organs. It mainly includes patients who can have the tumor completely removed and accurately staged using lymph node samples.
Tianjin, Tianjin MunicipalityAges 18–90 - NCT06965335Recruiting
Early-onset colorectal cancer study
This study looks at colorectal cancer that starts early in life (ages 18–40). It compares it to the same cancer in people over 60 to find differences. You can join if you have had colorectal cancer and can provide a sample of your tumor.
Milan, MilanoAges 18–40 - NCT05787197Recruiting
Blood test to guide treatment after colon cancer liver surgery
This trial studies a blood test (called ctDNA) in people with colon cancer that has spread to the liver and is being removed with curative surgery. The goal is to see how the blood test can help with planning and improving treatment after surgery.
BesançonAges 18 years+ - NCT06746012Recruiting
Health app study for colorectal cancer survivors and their caregivers
This study tests a mobile health program to help colorectal cancer survivors and their family caregivers stick to healthy lifestyle habits. It's for survivors who are at least 6 months past treatment and have a smartphone.
Columbus, OhioAges 18 years+ - NCT04920149RecruitingPhase 2
Mesalamine to help prevent colon cancer in Lynch syndrome
This trial tests whether mesalamine, a medicine used for bowel inflammation, can help prevent colorectal cancer in people with Lynch syndrome who do not currently have cancer. It may help by lowering the chance that new pre-cancer growths form over time.
AalborgAges 30 years+
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Common questions
- Are there clinical trials for colorectal cancer (crc)?
- Yes. Clin2 currently lists 320 recruiting colorectal cancer (crc) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (crc) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (crc) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.