Clinical trials · St. Louis, MO
Dementia clinical trials in St. Louis
We’re tracking 16 recruiting dementia studies with a site in or near St. Louis — including Phase 2, Phase 2/Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near St. Louis
- NCT05704309Enrolling by invitation
Study of diabetes prevention participants using brain scans
This study looks at how people who previously took part in a diabetes prevention program are doing over time, including brain health using MRI scans for some participants. It may help researchers understand who is at higher risk for memory and thinking problems and why.
St Louis, MissouriAges Any age - NCT06647498RecruitingPhase 2/Phase 3
Study of a treatment for early-onset Alzheimer's caused by a gene change
This study tests a potential disease-modifying treatment for people who have a specific gene mutation that causes early-onset Alzheimer's disease. The goal is to see if the treatment can delay or prevent symptoms.
St Louis, MissouriAges 18 years+ - NCT07040904Recruiting
Mindfulness to help older Latino adults stay mentally sharp
This study tests whether mindfulness training can help older Latino adults stay sharp as they age. Researchers will measure changes in thinking skills and brain health.
St Louis, MissouriAges 65 years+ - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
St Louis, MissouriAges 18 years+ - NCT06547099Recruiting
Understanding new blood markers in memory loss and dementia
This study is looking for older adults (60+) to help researchers better understand how to detect and track memory changes and dementia. Participants will provide blood samples and other health information over time to identify new markers that might help with early diagnosis.
St Louis, MissouriAges 60 years+ - NCT06129838Recruiting
Inflammation in Alzheimer's disease using a brain scan
This study uses a special PET scan to look for inflammation in the brains of people with Alzheimer's or related dementias. It may help researchers understand how inflammation affects memory and thinking problems.
St Louis, MissouriAges 50 years+ - NCT05617014Enrolling by invitation
ADNI4 study for early Alzheimer’s with brain imaging tests
This study enrolls people with no memory impairment, mild memory problems, or mild Alzheimer’s dementia to test how brain scans and cognitive tests relate to Alzheimer’s disease. It may help by contributing to better early diagnosis and by letting you see whether you fit into the study’s imaging and blood-test pathway.
St Louis, MissouriAges 55–90 - NCT02763683Recruiting
Study brain changes in Parkinson-related dementia
This study looks at brain features linked to dementia in people who have Parkinson disease. It may help researchers understand why dementia happens in Parkinson and how it could be detected or treated in the future.
St Louis, MissouriAges 50 years+ - NCT04165109Recruiting
Down syndrome study to test memory and thinking changes
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
St Louis, MissouriAges 25–55 - NCT03623672Enrolling by invitation
Study for early signs of Parkinson-related brain changes
This study enrolls people with idiopathic REM sleep behavior disorder, a sleep problem that can come before Parkinson’s disease or related conditions. It aims to better understand early (“prodromal”) changes so future treatments can be targeted earlier.
St Louis, MissouriAges 18 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
St Louis, MissouriAges 75 years+ - NCT04579120Recruiting
Brain scan study in healthy aging or early Alzheimer’s
This study uses brain imaging to understand changes in the brain during normal aging and early Alzheimer’s disease (AD). It may help researchers spot early brain changes and evaluate how well imaging measures those changes.
St Louis, MissouriAges 18 years+ - NCT05552157RecruitingPhase 2/Phase 3
Study of treatments for early onset Alzheimer's caused by genetic mutations
This trial tests potential treatments for people who are at risk for or have early onset Alzheimer's disease due to a specific genetic mutation. It aims to find treatments that could slow or prevent symptoms.
St Louis, MissouriAges 18 years+ - NCT05543681RecruitingPhase 2
Study drug for agitation in Alzheimer’s dementia with caregiver support
This Phase 2 trial tests a study medicine to reduce “agitation” behaviors in people with Alzheimer’s dementia. You and your caregiver would complete required assessments and may need genetic and blood testing to check how the body handles the drug.
St Louis, MissouriAges 60 years+ - NCT05826457Enrolling by invitation
Study for early RBD as a possible Parkinson’s risk
This study looks at people with REM sleep behavior disorder (RBD), confirmed by a sleep test, who may be in the early “prodromal” stage before Parkinson’s or related diseases. It also enrolls healthy controls to compare results from brain and body testing to better understand who is at risk.
St Louis, MissouriAges 18 years+ - NCT07284472RecruitingPhase 2/Phase 3
Testing drugs for agitation in Alzheimer's disease
This trial tests two new drugs (EXV-802 and EXV-801) to see if they can safely reduce moderate to severe agitation in people with Alzheimer's dementia. If you or a loved one has Alzheimer's and has been experiencing significant agitation for at least two weeks, this study may be an option.
Chesterfield, MissouriAges 55–90
Hear when a new Dementia trial opens near St. Louis, MO
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Dementia trials in other cities
Where these studies are running near St. Louis
Institutions with a site for the recruiting dementia studies listed above.
- Washington University in St. Louis · 13 studies
- Galen Research
- St. Louis VA Medical Center John Cochran Division
- Tekton Research
- Washinton University in St. Louis
What taking part in a dementia study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting dementia studies in Missouri.
Common questions
- Are there dementia clinical trials near St. Louis?
- Yes. We're currently tracking 16 recruiting dementia studies with a site near St. Louis, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a dementia study near St. Louis?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in St. Louis to take part?
- Not necessarily. These studies have a site near St. Louis, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a dementia trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New dementia studies open near St. Louis regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.