Clinical trials · North Carolina
Dementia clinical trials in North Carolina
We’re tracking 19 recruiting dementia studies with a site in North Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06245031Enrolling by invitation
Long-term follow-up of sensory stimulation for Alzheimer's
This is a follow-up study for people who already completed the 12-month Hope Study (CA-0011). It tests long-term safety and effects of a gentle sensory stimulation device (light and sound) for Alzheimer's disease. You will continue using the device at home with a study partner.
Matthews, North CarolinaAges 50–92 - NCT06854718Recruiting
Pain Management Study for People with Dementia
This study tests a new approach to help people with dementia who have chronic pain. It looks at how caregivers can support pain management at home.
Durham, North CarolinaAges 50 years+ - NCT07029581RecruitingPhase 2
Testing ACP-204 for psychosis in Lewy body dementia
This trial tests a new drug called ACP-204 for people with dementia from Lewy body disease or Parkinson's who also have hallucinations or delusions. The goal is to see if the drug can safely reduce these symptoms without worsening thinking problems.
Chapel Hill, North CarolinaAges 55–84 - NCT06651567RecruitingPhase 2
Study of ITI-1284 for agitation in Alzheimer's
This trial tests an experimental drug called ITI-1284 to see if it can reduce agitation in people with Alzheimer's disease. It may help if you or your loved one experiences significant agitation related to Alzheimer's.
Raleigh, North CarolinaAges 55 years+ - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Chapel Hill, North CarolinaAges 18 years+ - NCT03233646Recruiting
Retina scans in memory and nerve disorders
This study uses pictures of the back of your eye (retinal imaging) to look for differences in people with neurodegenerative diseases and compares them with people without these conditions. It may help researchers understand eye changes that could connect to brain or nerve health.
Durham, North CarolinaAges 18 years+ - NCT06239688Recruiting
Training program to improve dementia care in assisted living
This study tests a new training program meant to help staff at assisted living communities better care for people with dementia. It also invites family members to share their experiences to improve how care is given.
Chapel Hill, North CarolinaAges 18 years+ - NCT06565169Recruiting
Helping primary care doctors support advance care planning for dementia
This study tests a training tool to help primary care teams talk about future care wishes with people who have Alzheimer's or related dementias. It aims to improve advance care planning for older adults with dementia.
Chapel Hill, North CarolinaAges 18–99 - NCT06840587Recruiting
Connect-Home: Alzheimer's and related dementias study
This trial tests a program to help people with dementia and their caregivers prepare for a safe move from a skilled nursing facility to home or another care setting. It aims to improve the transition and support both the patient and caregiver.
Chapel Hill, North CarolinaAges 19 years+ - NCT05973448Enrolling by invitation
Nightlight Falls Prevention for People With Dementia
This study tests a simple plan to help prevent falls in people who have dementia. You may be able to join if you live in a participating assisted living community and meet the safety and room rules.
Chapel Hill, North CarolinaAges 18 years+ - NCT05617014Enrolling by invitation
ADNI4 study for early Alzheimer’s with brain imaging tests
This study enrolls people with no memory impairment, mild memory problems, or mild Alzheimer’s dementia to test how brain scans and cognitive tests relate to Alzheimer’s disease. It may help by contributing to better early diagnosis and by letting you see whether you fit into the study’s imaging and blood-test pathway.
Durham, North CarolinaAges 55–90 - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT03489278Recruiting
Support procedures study for ALS using electronic health records
This study is about improving the research process for people with ALS by using electronic health records from participating clinics. If you have ALS and receive care at an Epic-using center, you may be asked to help with consent and study procedures.
Winston-Salem, North CarolinaAges 18 years+ - NCT03848312RecruitingPhase 3
Preventing Alzheimer’s with brain training for older adults
This Phase 3 study tests whether structured computer brain-training can help prevent Alzheimer’s-related thinking problems. You may be more likely to benefit if your thinking is currently normal, and you can safely do the computer exercises every schedule the study requires.
Durham, North CarolinaAges 65 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Asheville, North CarolinaAges 75 years+ - NCT04916210Recruiting
Study how stroke type affects thinking and recovery
This study looks at what predicts memory and thinking problems after different types of stroke or brain bleeding, and how blood-vessel changes relate to recovery. You may be invited if you recently had a stroke/bleed and can complete a baseline check within 6 weeks.
Winston-Salem, North CarolinaAges 18 years+ - NCT06088810Recruiting
Can music improve sleep for people with dementia?
This study tests whether listening to music can help people with dementia sleep better. You and a caregiver will participate together.
Durham, North CarolinaAges 18–100 - NCT06703541Recruiting
Alzheimer's disease research study with brain scans and spinal tap
This study at Duke University is looking for people aged 25 to 80 who may be at risk for Alzheimer's disease. It involves brain scans (MRI and PET) and a spinal tap to learn more about the disease and find better ways to detect and treat it early.
Durham, North CarolinaAges 25–80 - NCT07602582RecruitingPhase 3
Donanemab Extension Study for Alzheimer's Disease
This is a follow-up study for people who already completed a previous donanemab trial (AACM). Donanemab is a medication designed to slow cognitive decline in early Alzheimer's disease by targeting amyloid buildup in the brain.
Monroe, North CarolinaAges 55 years+
Dementia trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting dementia studies listed above.
- University of North Carolina at Chapel Hill · 7 studies
- Duke University Medical Center · 4 studies
- Duke University · 3 studies
- Wake Forest University Health Sciences · 3 studies
- Duke University Health System · 2 studies
- AMC Research, LLC
- Asheville VA-Charles George VA Medical Center
- Atrium Health
What taking part in a dementia study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Dementia trials in other states
Common questions
- Are there dementia clinical trials in North Carolina?
- Yes. We're currently tracking 19 recruiting dementia studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a dementia study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a dementia trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New dementia studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.