Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 689 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06983405Recruiting
Physical therapy for depression and quality of life pilot
This study is testing whether adding physical therapy to your usual depression care can improve your quality of life while you are in the hospital. If you are an adult admitted to the psychiatry unit with major depression, you may be able to join.
Zaragoza, AragonAges 18 years+ - NCT07193901RecruitingPhase 2
Nasal spray for depression with suicidal thoughts
This trial tests an experimental nasal spray for people with major depression who are currently having suicidal thoughts. It aims to see if the spray can quickly reduce depression and suicidal feelings.
BeijingAges 18–64 - NCT07197138Recruiting
TMS for depression with long COVID
This trial tests whether accelerated TMS (a brain stimulation treatment) can help people with depression who also have long COVID. It may be an option if your depression hasn't improved enough with medication alone.
Munich, BavariaAges 18–65 - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT06892613Recruiting
Couples therapy for depression and anxiety in married couples
This trial compares two types of couples therapy (EFCT and BCT) to see which works better for depression and anxiety. If you and your spouse are feeling stressed, anxious, or low, this study may help you strengthen your relationship and improve your mood.
Istanbul, IstanbulAges 18–65 - NCT06966921Recruiting
Brain stimulation for thinking, mood, and sleep in mental illness
This trial tests if a gentle electrical device placed on your head (cranial electrotherapy) can improve thinking, mood, and sleep for people living with chronic mental health conditions. It's a non-invasive approach that might help with anxiety or depression without medication side effects.
Nantou CityAges 20–75 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06537921Recruiting
Testing minocycline for depression with obesity
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
LondonAges 18–65 - NCT07022184Recruiting
Lifestyle app for depression with GP support
This trial tests a lifestyle app to help people with depression who are under a GP's care. It looks at whether using the app alongside your usual treatment can improve your mood.
Nijmegen, GelderlandAges 18 years+ - NCT07554755Recruiting
Transcranial Stimulation for Teen Depression with Self-Injury
This trial tests a non-invasive brain stimulation treatment (TIS) for teenagers aged 12–22 with depression who injure themselves without wanting to die. The goal is to reduce depression symptoms and self-injury urges.
Hefei, AnhuiAges 12–22 - NCT05950698Recruiting
Study of obesity and bariatric surgery with mental and social factors
This study looks at how personal mental health and life circumstances relate to outcomes after bariatric (weight-loss) surgery. It may help the team understand what supports improve recovery and health after surgery.
Rio de Janeiro, Rio de Janeiro, BrazilAges 18–60 - NCT07651436Recruiting
Depression screening in patients on kidney dialysis
This study tests whether nurses can effectively screen for depression in patients receiving regular kidney dialysis treatment. The goal is to find the best way to identify depression early so patients can get help.
AnnecyAges 18 years+ - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Los Angeles, CaliforniaAges 18–75 - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT07388004Recruiting
Comparing two group therapies for depression
This trial compares two types of group therapy for major depression: one that focuses on changing your expectations about the future, and another that helps you reconnect with rewarding activities. The goal is to see which approach works better for reducing depression symptoms.
Marburg, HesseAges 18–80 - NCT06906003Recruiting
Vision rehab and depression in age-related macular degeneration
This trial tests whether visual rehabilitation can help improve both vision and mood in people with advanced dry age-related macular degeneration. It aims to understand the link between vision loss and depression.
Rome, ItalyAges 55 years+ - NCT06702761Recruiting
Depression among heart surgery healthcare workers in Baghdad
This study aims to find out how common and how severe depression is among healthcare workers in cardiothoracic surgery departments in Baghdad. It uses a questionnaire called PHQ-9 to screen for depression symptoms.
BaghdadAges 18 years+ - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT05613972Recruiting
Combined therapy for adults with suicidal thoughts and childhood trauma
This study tests a new combination of talk therapies for adults who have both suicidal thoughts and a history of childhood trauma. The goal is to see if this combined approach reduces suicide risk better than usual care.
Toronto, OntarioAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT06907654Recruiting
Couples' affect and relationships study
This study looks at how couples' moods and relationships interact over time. You and your partner will use a smartphone app and respond to daily text surveys for 3 weeks.
Madison, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 689 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.