Clin2
NCT05877885Possibly a fitRecruiting

Digital treatment for low motivation in older adults with depression

Major Depressive DisorderApathy

Part of Brain & nervous system, Mental health clinical trials.

This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
84 people
Ages
60 years and older
Study type
Interventional

Who can take part

  • Be age 60 or older
  • Have depression (major depressive disorder) without hallucinations or delusions
  • Have a moderate-to-severe depression score and clinically significant apathy
  • Be able to stay on the same antidepressant dose (or be off antidepressants) for required time windows
  • Be able to do an MRI and participate using an English computer/tablet with Wi‑Fi

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07237009Recruiting
Personalized reminiscence therapy for memory loss

This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.

Angers
NCT04757220Recruiting
Study of apathy in people with schizophrenia or depression

This study looks at “apathy,” or reduced motivation/interest, in people with schizophrenia or depression. It may help researchers understand what drives apathy and how to measure it in a clearer, more complete way.

Strasbourg
NCT07279740Recruiting· Phase 2
Brain stimulation plus medication for apathy in dementia

This study tests if combining a type of brain stimulation (repetitive TMS) with a medication (methylphenidate, commonly used for ADHD) can improve apathy in people with dementia. If you have Alzheimer's or mixed dementia and struggle with low motivation, this trial may help you.

Toronto, Ontario
NCT06910683Not yet recruiting
Technology program to help with depression in older adults

This study is testing a new technology-based program to help people with depression aged 50 to 80 feel more connected and engaged. It involves brain imaging (MRI) and aims to see if this approach can improve mood and daily functioning.

New York, New York
NCT07527273Not yet recruiting
Improving thinking in older adults with recurring depression

This study tests whether adding a type of brain stimulation called transcranial direct current stimulation (tDCS) to a computer-based cognitive training program can improve thinking and memory problems in older adults who have had repeated episodes of depression. The goal is to see if this combined treatment can help boost executive function — the skills you use to plan, focus, and organize.

Nashville, Tennessee
NCT06732089Recruiting
Digital help for stubborn depression

This trial tests a digital program (smartphone app or website) to help people with tough-to-treat depression. If you are already receiving advanced treatments like rTMS, ketamine, or ECT at St. Michael's Hospital, you may be able to join and see if this extra digital support improves your mood.

Toronto, Ontario

Hear when a new Major Depressive Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.