Clinical trials
Depression in Adults clinical trials
Below are recruiting depression in adults clinical trials, each written for real people, not researchers. We’re tracking 89 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06732089Recruiting
Digital help for stubborn depression
This trial tests a digital program (smartphone app or website) to help people with tough-to-treat depression. If you are already receiving advanced treatments like rTMS, ketamine, or ECT at St. Michael's Hospital, you may be able to join and see if this extra digital support improves your mood.
Toronto, OntarioAges 18 years+ - NCT06721559Recruiting
Home program for older adults with depression and mobility issues
This study tests a home-based program called Empower@Home for older adults who have depression and trouble moving around. It aims to see if the program helps improve mood and daily life—without adding extra outside therapy.
Ann Arbor, MichiganAges 50 years+ - NCT05802004Recruiting
Sound stimulation to improve sleep and emotions in young adults
This study tests whether gentle sound stimulation during sleep can improve sleep and how you think and feel in daily life when you have anxiety or depression symptoms. You’ll also do sleep testing in a lab and complete questionnaires to measure changes.
Pittsburgh, PennsylvaniaAges 18–25 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Birmingham, AlabamaAges 18–75 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bryant, ArkansasAges 18–74 - NCT06797804Recruiting
Horticultural therapy for older adults in long-term care
This study tests if an app-guided gardening program can improve heart health, reduce stress and depression, and boost happiness in older adults living in nursing homes. It aims to see if these sessions can help you feel better overall.
TaipeiAges 65 years+ - NCT07413874Recruiting
Music therapy over video for depression and hormone disorder
This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.
Boone, North CarolinaAges 18–65 - NCT06654414Recruiting
Smoking cessation support for transgender and gender-diverse adults
This study tests a skills-based program to help transgender and gender-diverse adults quit smoking or vaping. The program focuses on managing stress related to identity and health, and may be more supportive than standard quit programs.
Boston, MassachusettsAges 18 years+ - NCT06290063RecruitingPhase 2
CBD for older adults who use cannabis
This study tests whether a pure CBD product (Epidiolex) can help older adults who use cannabis occasionally. It looks at how CBD affects people who already take medications for pain, sleep, or mood issues.
Boulder, ColoradoAges 60 years+ - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Birmingham, AlabamaAges 18–74 - NCT07475039Recruiting
Friendly phone calls to support older adults
This study tests whether a program of friendly phone calls from trained volunteers can help older adults feel more connected and supported. If you are 65 or older and already receive home-delivered meals or other services, you may be able to join.
Gainesville, FloridaAges 55 years+ - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT06978166Recruiting
Digital therapy for chronic pain and mood
This study tests a smartphone app that gives you personalized tips and exercises to help manage chronic pain along with depression or anxiety. It is designed for adults ages 45 and older and aims to see if these digital check-ins can improve how you feel day to day.
St Louis, MissouriAges 45 years+ - NCT07652775Recruiting
Brain stimulation and exercise for memory and mood
This study tests whether combining rTMS (a non‑invasive brain stimulation) with aerobic exercise can improve memory, thinking, and mood in older adults who have mild memory problems and depression. It may offer a safe, drug‑free way to help both brain health and emotional well‑being.
Taipei, Taipei CityAges 65–90 - NCT06967857RecruitingPhase 2
Dexamfetamine for adults with ADHD and depression
This trial tests a study medication (dexamfetamine) for adults who have both ADHD and moderate to severe depression. It aims to see if the medication is safe and helps improve both conditions.
BerlinAges 18–65 - NCT07117058Recruiting
Anxiety and depression screening for young cancer survivors
This study tests a quick tool to identify anxiety or depression in children, teens, and young adults who have finished intensive cancer treatment and are now in remission. It aims to help doctors provide better mental health support.
AngersAges 7–25 - NCT06604481Recruiting
Online coaching for family caregivers
This study tests a 6-week online coaching program to help family caregivers reduce stress and build resilience. You'll learn practical strategies you can use at home.
Hong KongAges 18 years+ - NCT07765355Recruiting
Virtual nature for anxiety in hospitalized older adults
This trial tests whether watching virtual nature scenes or guided imagery can help reduce anxiety and improve well-being in older adults while they are in the hospital. It may offer a calming, drug-free way to support your mental health during a hospital stay.
BudapestAges 65 years+ - NCT06745349Recruiting
Online sleep course for adults in Saskatchewan
This study tests an online sleep course for adults who have trouble falling or staying asleep. It aims to help improve sleep without requiring in-person visits.
Regina, SaskatchewanAges 18 years+ - NCT07241325Recruiting
Emotional health and quality of life in type 2 diabetes
This study looks at how adults with type 2 diabetes feel emotionally and mentally, and how their health affects their daily life. Participants will fill out questionnaires about their mood, well-being, and quality of life.
TaipeiAges 18 years+ - NCT07398365Recruiting
Medical study of psychiatry inpatients
This study looks at the medical and mental health patterns of adults admitted to general adult psychiatry wards. It aims to better understand their health needs.
Livingston, West LothianAges 18–65 - NCT07369180Enrolling by invitation
TMS for treatment-resistant depression in adults
This study tests a new type of transcranial magnetic stimulation (TMS) for adults whose depression hasn't gotten better with medication. It compares the real treatment to a sham (inactive) version to see how well it works.
Campbell, CaliforniaAges 22–85 - NCT05685368RecruitingPhase 1/Phase 2
Therapy groups to help teens cope with sickle cell
This trial tests a structured talk-therapy program called Acceptance and Commitment Therapy (ACT) for teens and young adults with sickle cell disease. It aims to help you manage tough thoughts and feelings and cope with day-to-day challenges over 6 weekly group sessions.
Los Angeles, CaliforniaAges 14–21 - NCT07768670Recruiting
Smartphone exercise program for older adults
This study tests a personalized exercise program delivered through a smartphone app to help older adults become more active. You would use the app to get exercise recommendations and track your progress.
Knoxville, TennesseeAges 65 years+
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Common questions
- Are there clinical trials for depression in adults?
- Yes. Clin2 currently lists 89 recruiting depression in adults studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression in adults trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression in adults trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.