Seltorexant for Depression in Adults and Older Adults
Part of Mental health clinical trials.
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with major depressive disorder (depression without hallucinations or delusions) for at least 2 weeks
- Either never treated with antidepressants before, or tried up to 2 antidepressants in this current episode that didn't work or caused side effects
- Body mass index between 18 and 40 (generally healthy weight range)
- Medically stable with normal heart rhythm, blood pressure, and physical exam results
- No history of bipolar disorder, psychosis, substance abuse in the past 6 months, or severe suicidal thoughts/behavior in the past 3 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
This study tests a new medicine called ammoxetine for people with major depression. It aims to see if it can help reduce depressive symptoms.
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
This trial is for teenagers whose depression has not improved after trying one SSRI antidepressant. It compares switching to a different medication versus adding another medication to see which approach works better.
Hear when a new Depressive Disorder, Major trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.