Clinical trials · Boston, MA
Depression clinical trials in Boston
We’re tracking 108 recruiting depression studies with a site in or near Boston — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT07779707Recruiting
Medically tailored groceries for depression and food insecurity
This study tests whether getting free, healthy groceries tailored to your medical needs can help improve symptoms of depression. If you are struggling with both depression and having enough food, this program might give you extra support.
Worcester, MassachusettsAges 18 years+ - NCT06017622Recruiting
THC Levels in Young People with Cannabis Overdose in the ER
This study looks at the amount of THC (the active ingredient in cannabis) in the blood of children and teens who come to the emergency room with severe drowsiness or confusion after using cannabis. It will help doctors better understand how cannabis affects young people.
Worcester, MassachusettsAges Any age - NCT06903897Recruiting
Social Needs Screening for Chronic Disease Study
This study looks at how asking about social needs (like food, housing, or money worries) can help people with chronic conditions like high blood pressure, diabetes, asthma, or depression. It takes place in Family Medicine clinics and aims to improve overall health.
Worcester, MassachusettsAges Any age - NCT07210255Recruiting
SAINT TMS for postpartum depression
This trial tests a special type of TMS (brain stimulation) called SAINT for severe depression that started around childbirth. It may help new mothers who are still within a year postpartum and have not found relief from other treatments.
Worcester, MassachusettsAges 18–45 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Worcester, MassachusettsAges 18–64 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
East Providence, Rhode IslandAges 12–17 - NCT06737055Recruiting
Sleep help for new and expectant parents
This study tests a sleep program for pregnant women and new moms. It uses specially trained helpers to teach better sleep habits, which may improve your rest and well-being.
Providence, Rhode IslandAges 18–99 - NCT06882798Recruiting
New support program for Latinx teens with suicidal thoughts
This study tests a new support program for Latinx teens who have had serious thoughts about suicide or a suicide crisis in the past year. It involves working with both you and your family to find ways to help you feel safer and more supported.
Providence, Rhode IslandAges 12–18 - NCT07594743Recruiting
Digital app to prevent depression in new fathers
This study tests a smartphone app designed to help fathers manage stress and mood after their baby is born. Researchers want to see if fathers find the app helpful and easy to use during this major life change.
Providence, Rhode IslandAges 18 years+ - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+ - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+
Hear when a new Depression trial opens near Boston, MA
We’ll email you when one opens near Boston, MA — at most once a week, no account needed, unsubscribe anytime.
Depression trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting depression studies listed above.
- Butler Hospital · 3 studies
- University of Massachusetts Chan Medical School · 3 studies
- Boston Children's Hospital
- Bradley Hospital
- Community Care Cooperative (C3)
- Family Health Center of Worcester
- Hasbro Children's Hospital
- Rhode Island Hospital
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Massachusetts.
Common questions
- Are there depression clinical trials near Boston?
- Yes. We're currently tracking 108 recruiting depression studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.