Clinical trials · Los Angeles, CA
Depression clinical trials in Los Angeles
We’re tracking 74 recruiting depression studies with a site in or near Los Angeles — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Los Angeles
- NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Los Angeles, CaliforniaAges 22–70 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Los Angeles, CaliforniaAges 18–65 - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Los Angeles, CaliforniaAges 18–65 - NCT06345859RecruitingPhase 2
Brain and emotion study for young adults with or without depression history
This study looks at how the brain regulates mood and body signals in young adults ages 18-27. It includes people who have had depression in the past but are now well, as well as healthy volunteers with no psychiatric history.
Los Angeles, CaliforniaAges 18–27 - NCT06856057Recruiting
Support for caregivers and kids after injury
This study helps parents and young children cope with stress after a hospital stay for an injury. It tests a program to improve mental health for both caregivers and kids.
Los Angeles, CaliforniaAges 18 years+ - NCT06572683Enrolling by invitation
Novel TMS for hard-to-treat depression
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
Los Angeles, CaliforniaAges 21–75 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Los Angeles, CaliforniaAges 18–85 - NCT07577947Recruiting
Digital tracking to help treat pregnancy and postpartum depression
This study tests whether wearing an Apple Watch and using a smartphone app can help doctors better understand and treat depression during pregnancy and after birth. You'll receive depression treatment through the study while the app and watch track your daily patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT07219875RecruitingPhase 2
Training the Brain to Enjoy Life Through Virtual Reality
This study tests whether a virtual reality (VR) program can help people with depression feel more motivated and enjoy activities again. You'll use a VR headset to practice responding to rewarding experiences, which may boost positive moods.
Los Angeles, CaliforniaAges 18 years+ - NCT04556890Recruiting
Brain stimulation for treatment-resistant depression and chronic pain
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT06639477Recruiting
Mood and sleep improvement study for older adults
This study tests whether adding a sleep treatment to regular depression medication can improve both mood and sleep in adults aged 55 and older. It may help if you have ongoing depression, sleep problems, and are already taking antidepressant medication.
Los Angeles, CaliforniaAges 55 years+ - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Los Angeles, CaliforniaAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Los Angeles, CaliforniaAges 18–70 - NCT06139861Recruiting
Better Sleep Study
This study tests a program to help you sleep better. It is for people who are generally healthy and do not have serious medical or mental health conditions.
Los Angeles, CaliforniaAges 12–18 - NCT05329441Recruiting
Testing an anti-depression medicine for threat-related brain changes in teens
This trial studies how fluoxetine or escitalopram (anti-depression medicines) may affect brain systems involved in feeling threatened and staying anxious when you have depression. It also uses brain scanning and blood tests to measure these changes.
Los Angeles, CaliforniaAges 14–21 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
Los Angeles, CaliforniaAges 18 years+ - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Los Angeles, CaliforniaAges 18 years+ - NCT06874790Recruiting
Web-based mental health app study for Latina women
This study tests a web-based app to help Latina women in Los Angeles or Orange County who are feeling anxious or depressed. If you are not currently in therapy or on medication, you may be able to join from home using your smartphone or computer.
Los Angeles, CaliforniaAges 18 years+ - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Los Angeles, CaliforniaAges 18–50 - NCT06002100Enrolling by invitation
Predicting depression treatment response with brain imaging
This study uses a special headband (TD-fNIRS) that measures brain activity to see if it can predict how well different depression treatments work. You would be starting a new treatment for depression (like ketamine, SPRAVATO, TMS, or antidepressants) and wear the headband before and during treatment.
Los Angeles, CaliforniaAges 18–75 - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Los Angeles, CaliforniaAges 18–75 - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Los Angeles, CaliforniaAges 18–70 - NCT06175104Recruiting
HeartGPS: Support for parents after a prenatal heart diagnosis
This study tests a counseling program for parents whose unborn baby has a serious heart condition called single ventricle. The program aims to help parents manage stress and support their baby's development before and after birth.
Los Angeles, CaliforniaAges 18 years+
Hear when a new Depression trial opens near Los Angeles, CA
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Depression trials in other cities
Where these studies are running near Los Angeles
Institutions with a site for the recruiting depression studies listed above.
- University of California, Los Angeles (UCLA) · 8 studies
- ATP Clinical Research · 3 studies
- Children's Hospital Los Angeles · 3 studies
- NRC Research Institute · 3 studies
- CalNeuro Research Group · 2 studies
- Clinical Site · 2 studies
- Neurocrine Clinical Site · 2 studies
- University of Southern California · 2 studies
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in California.
Common questions
- Are there depression clinical trials near Los Angeles?
- Yes. We're currently tracking 74 recruiting depression studies with a site near Los Angeles, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Los Angeles?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Los Angeles to take part?
- Not necessarily. These studies have a site near Los Angeles, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Los Angeles regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.