Clinical trials · San Francisco, CA
Depression clinical trials in San Francisco
We’re tracking 67 recruiting depression studies with a site in or near San Francisco — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near San Francisco
- NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
San Francisco, CaliforniaAges 18 years+ - NCT06455293RecruitingPhase 2
Psilocybin therapy for depression in Parkinson's disease
This study tests whether psilocybin, a substance found in certain mushrooms, can help improve depression in people with Parkinson's disease. If you have Parkinson's and are feeling depressed, this treatment may offer a new option.
San Francisco, CaliforniaAges 40–80 - NCT07573150Recruiting
Pupil Measurements to Predict Breathing Problems After Surgery in Children
This study tests whether measuring how a child's pupils (the dark circles in the eyes) respond to light can predict which children might have breathing problems after receiving pain medication during tonsil surgery. The goal is to help doctors catch and prevent serious breathing issues before they happen.
San Francisco, CaliforniaAges 3–17 - NCT06091527Recruiting
Yoga as a treatment for major depression
This trial tests whether practicing yoga alone (without medication or therapy) can help treat major depression. You would attend yoga sessions and learn how it affects your mood.
San Francisco, CaliforniaAges 18 years+ - NCT05152992Enrolling by invitation
Studying brain networks during epilepsy surgery planning
This study looks at how emotion-related brain connections change in space and over time while people with epilepsy are having surgery-related electrodes placed to find seizure sources. It may help researchers better understand brain networks and improve future treatment planning.
San Francisco, CaliforniaAges 18–80 - NCT05194098Recruiting
EEG and brain stimulation study for depression reward symptoms
This study uses non-invasive brain stimulation (like TMS) and EEG brain recordings to measure how the brain’s “reward” system works in people with major depression. It may help researchers understand which stimulation approaches best affect depression-related reward processing.
San Francisco, CaliforniaAges 18–65 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
San Francisco, CaliforniaAges 18–64 - NCT04581902Recruiting
Study blood and brain markers in moderate to severe depression
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
San Francisco, CaliforniaAges 18–70 - NCT06034821Enrolling by invitationPhase 4
ECT vs. ketamine for suicidal depression in adults
This trial compares two treatments—ECT (electroconvulsive therapy, which uses electrical stimulation) and ketamine (a medicine given as a shot)—to see which works better for quickly reducing suicidal depression. It is for adults who are in a severe depressive episode with active suicidal thoughts.
San Francisco, CaliforniaAges 18–90 - NCT07186816Recruiting
Peer support for Spanish-speaking adults with anxiety or depression
This trial tests whether peer support from someone who has been through similar struggles can help reduce anxiety and depression symptoms. It's for Spanish-speaking adults who have internet access and are not currently in talk therapy.
San Francisco, CaliforniaAges 18–100 - NCT04004169Recruiting
Closed-loop deep brain stimulation for long-lasting depression
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
San Francisco, CaliforniaAges 22–70 - NCT02434393Recruiting
Studying brain changes in late-life depression and memory decline
This study looks at how thinking and memory change in people with depression later in life, using brain imaging and related assessments. Your past participation and whether your treatments are stable enough around the time of the brain scan may determine whether you can join.
San Francisco, CaliforniaAges 65 years+ - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
San Francisco, CaliforniaAges 18–74 - NCT06080646Recruiting
Depression and Reward Processing Brain Study
This study uses brain scans (MRI) to understand how people with depression process rewards, aiming to identify different depression subtypes. You may join if you have depression or if you are a healthy volunteer.
San Francisco, CaliforniaAges 18–70 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
San Francisco, CaliforniaAges 18 years+ - NCT04061148Recruiting
Near-infrared testing to assess depression
This study uses a near-infrared light test to measure things related to depression. It includes people without depression and people diagnosed with major depressive disorder receiving care at UCSF/SFVAMC, to see how well the test fits with depression status.
San Francisco, CaliforniaAges 18 years+ - NCT06898788RecruitingEarly Phase 1
Probiotics for depression in teens and young adults
This study tests whether a probiotic supplement can help improve depression in young people who are already taking an SSRI antidepressant. If you join, you will take a probiotic or placebo for several weeks and have your mood and brain activity checked.
San Francisco, CaliforniaAges 15–24 - NCT05746767Enrolling by invitation
Spanish digital therapy coaching for depression and anxiety
This study tests a digital “cognitive behavioral therapy” program with peer support to help Spanish-speaking adults with depression or anxiety. It may help you manage symptoms using structured online tools and guided peer interaction.
San Francisco, CaliforniaAges 18 years+ - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
San Francisco, CaliforniaAges 18–50 - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
San Francisco, CaliforniaAges 18–85 - NCT06580041Enrolling by invitationPhase 4
Precision treatment for major depression
This trial tests a personalized approach to treating major depressive disorder using assessments and brain imaging to match you with the best therapy. It aims to improve outcomes by tailoring care to your specific needs.
San Francisco, CaliforniaAges 18 years+ - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Oakland, CaliforniaAges 18–80 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Oakland, CaliforniaAges 18–75
Hear when a new Depression trial opens near San Francisco, CA
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Depression trials in other cities
Where these studies are running near San Francisco
Institutions with a site for the recruiting depression studies listed above.
- University of California, San Francisco · 10 studies
- Zuckerberg San Francisco General Hospital and Trauma Center · 3 studies
- Kaiser Permanente-Oakland · 2 studies
- Neurocrine Clinical Site · 2 studies
- San Francisco VA Medical Center · 2 studies
- Castro-Mission Health Center
- John Muir Health
- Kaiser Permanente Deer Valley Medical Center
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in California.
Common questions
- Are there depression clinical trials near San Francisco?
- Yes. We're currently tracking 67 recruiting depression studies with a site near San Francisco, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near San Francisco?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Francisco to take part?
- Not necessarily. These studies have a site near San Francisco, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near San Francisco regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.